Construction of a Cancer Stem Cell Marker Genes-Related 22-Gene Signature for Overall Survival Prediction in High-Risk Wilms' Tumor.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI:10.1080/15513815.2024.2382277

Lihong Duan, Wudie Xia

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引用次数: 0

Abstract

Background: This study aimed to investigate the comprehensive expression profile of cancer stem cell (CSC)-related genes and construct a prognostic signature for overall survival (OS) prediction in high-risk Wilms' tumor (WT). Materials and methods: Gene expression and survival data from 120 high-risk WT cases in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET)-WT were used. Results: In total, 229 CSC-related genes were found to be significantly dysregulated in WT compared to tumor-adjacent normal tissues, among which 34 were associated with OS. Using LASSO regression, a 22-gene signature was developed, which exhibited excellent performance in 3-, 5-, and 10-year OS predictions (AUC > 0.86). The high-risk score group showed markedly poorer OS compared to the low-risk score group (median separation, HR = 6.41, 95% CI: 3.18-12.92, p = 3.2e - 9). The 22-gene signature was an independent prognostic factor for OS (HR = 5.086, 95% CI: 3.019-8.568, p < 0.001). Conclusion: This study identified a robust prognostic signature that can effectively support OS prediction.

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构建癌症干细胞标记基因相关的 22 个基因特征，用于预测高风险 Wilms 肿瘤的总体生存率

研究背景本研究旨在调查癌症干细胞（CSC）相关基因的综合表达谱，并构建高危Wilms's肿瘤（WT）总生存（OS）预测的预后特征。材料与方法使用 "治疗性研究产生有效治疗方法（TARGET）-WT "中120例高危WT病例的基因表达和生存数据。结果与肿瘤邻近的正常组织相比，共发现 229 个 CSC 相关基因在 WT 中明显失调，其中 34 个与 OS 相关。利用LASSO回归法建立了一个22个基因的特征，该特征在预测3年、5年和10年OS方面表现出色（AUC>0.86）。与低风险评分组相比，高风险评分组的 OS 明显较差（中位分离，HR = 6.41，95% CI：3.18-12.92，P = 3.2e - 9）。22个基因特征是OS的一个独立预后因素（HR = 5.086，95% CI：3.019-8.568，p 结论：该研究发现了一个稳健的预后特征，该特征是OS的一个独立预后因素：本研究发现了一种稳健的预后特征，可有效支持 OS 预测。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.