Filipe Tenório Lira, Lucas Ribeiro Campos, Matheus Roque, Sandro C Esteves
{"title":"From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected subfertile men.","authors":"Filipe Tenório Lira, Lucas Ribeiro Campos, Matheus Roque, Sandro C Esteves","doi":"10.1590/S1677-5538.IBJU.2024.9917","DOIUrl":null,"url":null,"abstract":"<p><p>Varicocele can reduce male fertility potential through various oxidative stress mechanisms. Excessive production of reactive oxygen species may overwhelm the sperm's defenses against oxidative stress, damaging the sperm chromatin. Sperm DNA fragmentation, in the form of DNA strand breaks, is recognized as a consequence of the oxidative stress cascade and is commonly found in the ejaculates of men with varicocele and fertility issues. This paper reviews the current knowledge regarding the association between varicocele, oxidative stress, sperm DNA fragmentation, and male infertility, and examines the role of varicocele repair in alleviating oxidative-sperm DNA fragmentation in these patients. Additionally, we highlight areas for further research to address knowledge gaps relevant to clinical practice.</p>","PeriodicalId":49283,"journal":{"name":"International Braz J Urol","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446552/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Braz J Urol","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/S1677-5538.IBJU.2024.9917","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Varicocele can reduce male fertility potential through various oxidative stress mechanisms. Excessive production of reactive oxygen species may overwhelm the sperm's defenses against oxidative stress, damaging the sperm chromatin. Sperm DNA fragmentation, in the form of DNA strand breaks, is recognized as a consequence of the oxidative stress cascade and is commonly found in the ejaculates of men with varicocele and fertility issues. This paper reviews the current knowledge regarding the association between varicocele, oxidative stress, sperm DNA fragmentation, and male infertility, and examines the role of varicocele repair in alleviating oxidative-sperm DNA fragmentation in these patients. Additionally, we highlight areas for further research to address knowledge gaps relevant to clinical practice.
精索静脉曲张会通过各种氧化应激机制降低男性的生育能力。过量产生的活性氧可能使精子无法抵御氧化应激，从而损害精子染色质。精子 DNA 断裂（以 DNA 链断裂的形式出现）被认为是氧化应激级联的结果，常见于患有精索静脉曲张和生育问题的男性的射精中。本文回顾了目前有关精索静脉曲张、氧化应激、精子 DNA 断裂和男性不育之间关系的知识，并探讨了精索静脉曲张修复在减轻这些患者的氧化-精子 DNA 断裂方面的作用。此外，我们还强调了需要进一步研究的领域，以解决与临床实践相关的知识缺口。
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
