Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality.

IF 6.9 1区 医学 Q1 IMMUNOLOGY
Samuel Phillips, Jon Hanger, Julien Grosmaire, Ahmed Mehdi, Martina Jelocnik, Jessie Wong, Peter Timms
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Abstract

In 2022, the Australian Government listed the koala as endangered in several states due to habitat destruction, traffic strikes, dog attacks, and Chlamydia pecorum disease. This study evaluates a 10-year assessment of a Major Outer Membrane Protein-based vaccine's effectiveness against chlamydial disease in wild koalas from Southeast Queensland. Over a decade, 680 koalas were tracked, with five vaccine trials involving 165 koalas. While prior studies only offered up to two years of data, this study's extended period allowed a thorough evaluation of vaccine efficacy. Results showed that vaccinated koalas had significantly lower disease incidence, with a 64% reduction in chlamydial mortality. This vaccine demonstrated positive impacts on both male and female koalas, highlighting its crucial role in conserving the Australian koala population and mitigating the threats they face.

Abstract Image

对考拉进行啄木鸟衣原体免疫接种可显著预防衣原体疾病和死亡率。
2022 年,由于栖息地遭到破坏、交通事故、狗的袭击以及啄木鸟衣原体疾病,澳大利亚政府将多个州的考拉列为濒危物种。本研究评估了一种基于主要外膜蛋白质的疫苗在昆士兰东南部野生考拉中预防衣原体疾病的十年效果。十年间,共对 680 只考拉进行了跟踪调查,其中五次疫苗试验涉及 165 只考拉。以前的研究最多只能提供两年的数据,而这项研究延长了时间,可以对疫苗的功效进行全面评估。结果显示,接种疫苗的考拉发病率明显降低,衣原体死亡率降低了 64%。这种疫苗对雄性和雌性考拉都产生了积极影响,凸显了它在保护澳大利亚考拉种群和减轻它们面临的威胁方面的重要作用。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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