Astrocytic activation increases blood flow in the adult olfactory bulb.

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2024-08-06 DOI:10.1186/s13041-024-01126-1

Takashi Ogino, Masakazu Agetsuma, Masato Sawada, Hiroyuki Inada, Junichi Nabekura, Kazunobu Sawamoto

引用次数: 0

Abstract

Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central nervous system. In the present study, using a chemogenetic method to induce astrocyte activation in mice without sensory stimulation, we found that astrocytic activation led to increased blood flow in the olfactory bulb, suggesting that astrocyte activation is sufficient for increasing blood flow in the olfactory bulb. The technique established here will be useful for studying the mechanisms underlying sensory input-dependent blood flow increases.

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星形胶质细胞的激活会增加成人嗅球的血流量。

据报道，感官刺激后星形胶质细胞的活化参与了中枢神经系统血流量的增加。在本研究中，我们使用化学遗传学方法诱导小鼠在没有感觉刺激的情况下激活星形胶质细胞，发现星形胶质细胞激活导致嗅球血流量增加，这表明星形胶质细胞激活足以增加嗅球血流量。本文建立的技术将有助于研究感觉输入依赖性血流增加的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.