Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation.

IF 3.5 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology

FEBS Letters Pub Date : 2024-08-06 DOI:10.1002/1873-3468.14991

Elisabetta Citterio, Antonella Ellena Ronchi

引用次数: 0

Abstract

Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness.

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造血干细胞衰老与骨髓增生异常转化之间相互作用的去泛素酶。

造血干细胞（HSC）终生维持造血功能。然而，造血干细胞的功能会随着生理衰老而退化，导致老年人血液病和造血恶性肿瘤的发病率增加。去泛素化酶（DUBs）通过还原蛋白质的泛素化来确保适当的蛋白稳态，这是造血干细胞维持和健康的关键过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.

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