Spatiotemporal whole-brain activity and functional connectivity of melodies recognition.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2024-08-01 DOI:10.1093/cercor/bhae320

Leonardo Bonetti, Elvira Brattico, Francesco Carlomagno, Joana Cabral, Angus Stevner, Gustavo Deco, Peter C Whybrow, Marcus Pearce, Dimitrios Pantazis, Peter Vuust, Morten L Kringelbach

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Abstract

Music is a non-verbal human language, built on logical, hierarchical structures, that offers excellent opportunities to explore how the brain processes complex spatiotemporal auditory sequences. Using the high temporal resolution of magnetoencephalography, we investigated the unfolding brain dynamics of 70 participants during the recognition of previously memorized musical sequences compared to novel sequences matched in terms of entropy and information content. Measures of both whole-brain activity and functional connectivity revealed a widespread brain network underlying the recognition of the memorized auditory sequences, which comprised primary auditory cortex, superior temporal gyrus, insula, frontal operculum, cingulate gyrus, orbitofrontal cortex, basal ganglia, thalamus, and hippocampus. Furthermore, while the auditory cortex responded mainly to the first tones of the sequences, the activity of higher-order brain areas such as the cingulate gyrus, frontal operculum, hippocampus, and orbitofrontal cortex largely increased over time during the recognition of the memorized versus novel musical sequences. In conclusion, using a wide range of analytical techniques spanning from decoding to functional connectivity and building on previous works, our study provided new insights into the spatiotemporal whole-brain mechanisms for conscious recognition of auditory sequences.

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旋律识别的时空全脑活动和功能连接。

音乐是一种非语言的人类语言，建立在逻辑和层次结构之上，为探索大脑如何处理复杂的时空听觉序列提供了绝佳的机会。利用脑磁图的高时间分辨率，我们研究了 70 名参与者在识别先前记忆的音乐序列与在熵和信息含量方面匹配的新序列时的大脑动态展开情况。对全脑活动和功能连接性的测量结果表明，在识别记忆的听觉序列时，大脑网络广泛存在，包括初级听觉皮层、颞上回、脑岛、额厣、扣带回、眶额皮层、基底神经节、丘脑和海马。此外，虽然听觉皮层主要对音序的第一个音作出反应，但在识别记忆音乐音序和新音乐音序的过程中，扣带回、额叶、海马和眶额皮层等高阶脑区的活动随着时间的推移大大增加。总之，我们的研究采用了从解码到功能连接的多种分析技术，并在前人研究的基础上，对有意识识别听觉序列的全脑时空机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.