Clinicopathologic features and new factors affecting constitution of eyelid neoplasms: a 10-year multicentre experience in southern coastal China.

IF 3.3 4区 医学 Q1 OPHTHALMOLOGY
Yu Wu, Hongliang Zhong, Zhenyang Xiang, Pin Zhou, Hui Wang, Xin Song, Yimin Li
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引用次数: 0

Abstract

Objective: This study aims to delineate the key characteristics of eyelid neoplasms in central and southern coastal China and to explore potential factors affecting tumour development.

Methods: This was a retrospective, multicentre observational study. In total, 1302 cases of eyelid neoplasms diagnosed in 2 tertiary hospitals were reviewed from January 2013 to May 2023. Histogenesis, pathologic diagnosis, and potential risk factors were investigated, and the findings were compared with data from various regions and countries. Age- and sex-specific incidence rates, time trends, distributions across age groups, and the relationship with the Sociodemographic Index, latitude, and altitude were calculated.

Results: There were 1162 benign (89.2%) and 140 malignant (10.8%) cases, representing 63 pathologic types. The median age of benign cases (50 years) was significantly lower than that of malignant cases (72 years) (P < 0.05). The most common benign and malignant lesions were intradermal nevus (28.83%) and basal cell carcinoma (BCC) (74.29%). A relatively younger median age (68 years) for sebaceous gland carcinoma (SGC) was observed, with a male preponderance (sex ratio 2:1). Analyses of the proportions of BCC, SGC, and squamous cell carcinoma in eyelid malignancies revealed significant regression equations (P < 0.05).

Conclusions: Most eyelid neoplasms are of epithelial and melanocytic origin, with benign tumours being predominant. The regions with greater Sociodemographic Index exhibit a greater incidence of BCC and a lower incidence of squamous cell carcinoma and SGC. BCC appears to have a greater incidence in regions located at higher latitudes.

影响眼睑肿瘤构成的临床病理特征和新因素:中国南部沿海地区多中心 10 年的经验。
背景:本研究旨在描述中国中部和南部沿海地区眼睑肿瘤的主要特征,并探讨影响肿瘤发展的潜在因素:本研究旨在描述中国中部和南部沿海地区眼睑肿瘤的主要特征,并探讨影响肿瘤发生的潜在因素:方法:这是一项多中心回顾性观察研究。方法:这是一项回顾性多中心观察研究。研究回顾了 2013 年 1 月至 2023 年 5 月期间在两家三甲医院确诊的 1302 例眼睑肿瘤病例。研究对组织发生、病理诊断和潜在风险因素进行了调查,并将调查结果与不同地区和国家的数据进行了比较。计算了特定年龄和性别的发病率、时间趋势、各年龄组的分布以及与社会人口指数、纬度和海拔的关系:共有 1162 例良性病例(占 89.2%)和 140 例恶性病例(占 10.8%),代表 63 种病理类型。良性病例的中位年龄(50 岁)明显低于恶性病例(72 岁)(P < 0.05)。最常见的良性和恶性病变是皮内痣(28.83%)和基底细胞癌(74.29%)。皮脂腺癌(SGC)的中位年龄相对较小(68 岁),男性居多(性别比为 2:1)。对眼睑恶性肿瘤中 BCC、SGC 和鳞状细胞癌的比例进行分析,发现了显著的回归方程(P < 0.05):结论:大多数眼睑肿瘤为上皮性和黑色素细胞性肿瘤,以良性肿瘤为主。社会人口指数较高的地区 BCC 发病率较高,鳞状细胞癌和 SGC 发病率较低。纬度较高地区的 BCC 发病率似乎更高。
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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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