Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy

IF 6.1 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Jianjing Lin, Jingtao Huang, Zilu Jiao, Mengyuan Nian, Canfeng Li, Yali Dai, Shicheng Jia, Xintao Zhang
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引用次数: 0

Abstract

Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration.
间充质干细胞治疗骨关节炎:相关细胞疗法的最新进展
骨关节炎(OA)是一种影响整个关节的退行性关节疾病,一直是全球医疗系统的巨大负担。尽管传统疗法和靶向软骨细胞疗法在治疗 OA 和软骨再生方面取得了重大进展,但仍存在许多问题。来自各种组织的间充质干细胞是研究最多的细胞类型,已被用于OA的临床前和临床研究,因为与自体软骨细胞相比,间充质干细胞的来源更广泛、体外扩增能力更强、具有抗炎和免疫调节特性。本文将系统回顾这些领域的最新进展。它可能会为改善 OA 和软骨再生提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioengineering & Translational Medicine
Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
8.40
自引率
4.10%
发文量
150
审稿时长
12 weeks
期刊介绍: Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.
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