Adaptive Gaussian Markov random fields for child mortality estimation.

IF 1.8 3区 数学 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Serge Aleshin-Guendel, Jon Wakefield
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引用次数: 0

Abstract

The under-5 mortality rate (U5MR), a critical health indicator, is typically estimated from household surveys in lower and middle income countries. Spatio-temporal disaggregation of household survey data can lead to highly variable estimates of U5MR, necessitating the usage of smoothing models which borrow information across space and time. The assumptions of common smoothing models may be unrealistic when certain time periods or regions are expected to have shocks in mortality relative to their neighbors, which can lead to oversmoothing of U5MR estimates. In this paper, we develop a spatial and temporal smoothing approach based on Gaussian Markov random field models which incorporate knowledge of these expected shocks in mortality. We demonstrate the potential for these models to improve upon alternatives not incorporating knowledge of expected shocks in a simulation study. We apply these models to estimate U5MR in Rwanda at the national level from 1985 to 2019, a time period which includes the Rwandan civil war and genocide.

用于儿童死亡率估算的自适应高斯马尔可夫随机场。
5 岁以下儿童死亡率(U5MR)是一项重要的健康指标,通常由中低收入国家的住户调查估算得出。对住户调查数据进行时空分类会导致 5 岁以下儿童死亡率的估算值变化很大,因此有必要使用平滑模型来借用跨时空的信息。当某些时间段或地区的死亡率相对于其邻近地区有冲击时,普通平滑模型的假设可能不切实际,从而导致五岁以下幼儿死亡率估计值的过度平滑。在本文中,我们开发了一种基于高斯马尔可夫随机场模型的时空平滑方法,其中包含了这些预期死亡率冲击的知识。在一项模拟研究中,我们展示了这些模型改进未纳入预期冲击知识的替代方法的潜力。我们应用这些模型估算了 1985 年至 2019 年卢旺达全国的五岁以下幼儿死亡率,这一时期包括卢旺达内战和种族灭绝。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biostatistics
Biostatistics 生物-数学与计算生物学
CiteScore
5.10
自引率
4.80%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Among the important scientific developments of the 20th century is the explosive growth in statistical reasoning and methods for application to studies of human health. Examples include developments in likelihood methods for inference, epidemiologic statistics, clinical trials, survival analysis, and statistical genetics. Substantive problems in public health and biomedical research have fueled the development of statistical methods, which in turn have improved our ability to draw valid inferences from data. The objective of Biostatistics is to advance statistical science and its application to problems of human health and disease, with the ultimate goal of advancing the public''s health.
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