Characterizing psychopharmacological prescribing practices in a large cohort of adolescents with borderline personality disorder.

IF 4 2区 医学 Q1 PSYCHIATRY
Sarah Hauryski, Alexandra Potts, Alison Swigart, Dara Babinski, Daniel A Waschbusch, Lauren N Forrest
{"title":"Characterizing psychopharmacological prescribing practices in a large cohort of adolescents with borderline personality disorder.","authors":"Sarah Hauryski, Alexandra Potts, Alison Swigart, Dara Babinski, Daniel A Waschbusch, Lauren N Forrest","doi":"10.1186/s40479-024-00262-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Psychiatric medications are not efficacious for treating borderline personality disorder (BPD), yet many patients with BPD are prescribed multiple psychiatric medications. This study aimed to (1) characterize psychiatric medication prescribing practices in adolescents with BPD and (2) assess whether demographic features are associated with prescribing practices.</p><p><strong>Method: </strong>This sample was N = 2950 pediatric patients with BPD (ages 10-19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.</p><p><strong>Results: </strong>Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).</p><p><strong>Conclusions: </strong>Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.</p>","PeriodicalId":48586,"journal":{"name":"Borderline Personality Disorder and Emotion Dysregulation","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302085/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Borderline Personality Disorder and Emotion Dysregulation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40479-024-00262-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Psychiatric medications are not efficacious for treating borderline personality disorder (BPD), yet many patients with BPD are prescribed multiple psychiatric medications. This study aimed to (1) characterize psychiatric medication prescribing practices in adolescents with BPD and (2) assess whether demographic features are associated with prescribing practices.

Method: This sample was N = 2950 pediatric patients with BPD (ages 10-19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.

Results: Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).

Conclusions: Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.

描述一大批患有边缘型人格障碍的青少年的精神药物处方实践。
背景:精神科药物对治疗边缘型人格障碍(BPD)效果不佳,但许多BPD患者却被处方多种精神科药物。本研究旨在:(1)描述患有边缘型人格障碍的青少年的精神科处方用药情况;(2)评估人口统计学特征是否与处方用药情况相关:数据来自NeuroBlu数据库,其中包括来自美国30个医疗保健系统和数百家医院的数据。泊松回归和卡方检验确定了性别、种族和民族是否与(1)处方的独特精神药物数量和(2)处方的独特药物类别数量相关:约有三分之二(64.85%)的青少年被处方任何药物。在这些青少年中,79.40%的人开出的处方中≥2种不同的药物,72.66%的人开出的处方中≥2种不同类别的药物。独特药物的平均数量为 3.50 种(标准差 = 2.50)。独特药物类别的平均数量为 2.35(SD = 1.15)。最常处方的药物类别是抗抑郁药和抗精神病药,这两种药物经常合并处方。泊松回归结果显示,男童的处方药数(M = 3.67)高于女童(M = 3.47)。非拉丁裔青少年所开具的独特药物(M = 44.12)明显多于拉丁裔青少年(M = 3.60,P = .01):结论:研究结果描述了患有 BPD 青少年的精神科处方用药情况。处方做法因人口统计学特征而异,如男孩和非拉丁裔青少年的处方用药量分别多于女孩和拉丁裔青少年。这些人口统计学差异表明,处方者可能会根据患者的人口统计学特征对BPD采取不同的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.00
自引率
9.80%
发文量
30
审稿时长
28 weeks
期刊介绍: Borderline Personality Disorder and Emotion Dysregulation provides a platform for researchers and clinicians interested in borderline personality disorder (BPD) as a currently highly challenging psychiatric disorder. Emotion dysregulation is at the core of BPD but also stands on its own as a major pathological component of the underlying neurobiology of various other psychiatric disorders. The journal focuses on the psychological, social and neurobiological aspects of emotion dysregulation as well as epidemiology, phenomenology, pathophysiology, treatment, neurobiology, genetics, and animal models of BPD.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信