Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife.

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2024-01-01 Epub Date: 2024-08-05 DOI:10.1159/000540336
Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley
{"title":"Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife.","authors":"Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley","doi":"10.1159/000540336","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Large neutral amino acids (LNAAs) tryptophan and phenylalanine have been implicated in the pathogenesis of neurodegenerative diseases. Given limited research on the effects of LNAA on brain health across different life stages, vascular risk, and genetic backgrounds, our study aimed to explore the interaction of LNAA levels, metabolic syndrome (MetS), and the presence of the apolipoprotein E ε4 (ApoE ε4) allele brain integrity at midlife.</p><p><strong>Methods: </strong>Sixty-eight adults aged 40-61 underwent a health assessment to calculate the number of MetS components, quantify LNAA, measure white matter hyperintensity (WMH) volume, and genotype ApoE ε4. Multivariate linear regression analyses were performed to test the joint effect of LNAA, MetS, and ApoE ε4 on WMH while adjusting for sex, age, and education.</p><p><strong>Results: </strong>Significant 3-way interactions were observed between serum tryptophan (β = 0.042, SE = 0.018, p &lt; 0.05) and phenylalanine (β = 0.044, SE = 0.013, p &lt; 0.01) levels, number of MetS components, and ApoE ε4 alleles status on WMH volume. Neither individual LNAA levels nor MetS components alone predicted WMH volume.</p><p><strong>Conclusions: </strong>The study highlights significant 3-way interactions between LNAA, MetS, and genetic risk factors in the pathology of WMH, particularly in individuals genetically predisposed to Alzheimer's disease. These interactions suggest differential impacts of LNAA on WMH volume dependent on both genetic and metabolic factors. Results emphasize the need for personalized metabolic and genetic profile assessments in neurodegenerative disease management.</p>","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":" ","pages":"113-121"},"PeriodicalIF":2.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385466/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lifestyle Genomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000540336","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Large neutral amino acids (LNAAs) tryptophan and phenylalanine have been implicated in the pathogenesis of neurodegenerative diseases. Given limited research on the effects of LNAA on brain health across different life stages, vascular risk, and genetic backgrounds, our study aimed to explore the interaction of LNAA levels, metabolic syndrome (MetS), and the presence of the apolipoprotein E ε4 (ApoE ε4) allele brain integrity at midlife.

Methods: Sixty-eight adults aged 40-61 underwent a health assessment to calculate the number of MetS components, quantify LNAA, measure white matter hyperintensity (WMH) volume, and genotype ApoE ε4. Multivariate linear regression analyses were performed to test the joint effect of LNAA, MetS, and ApoE ε4 on WMH while adjusting for sex, age, and education.

Results: Significant 3-way interactions were observed between serum tryptophan (β = 0.042, SE = 0.018, p < 0.05) and phenylalanine (β = 0.044, SE = 0.013, p < 0.01) levels, number of MetS components, and ApoE ε4 alleles status on WMH volume. Neither individual LNAA levels nor MetS components alone predicted WMH volume.

Conclusions: The study highlights significant 3-way interactions between LNAA, MetS, and genetic risk factors in the pathology of WMH, particularly in individuals genetically predisposed to Alzheimer's disease. These interactions suggest differential impacts of LNAA on WMH volume dependent on both genetic and metabolic factors. Results emphasize the need for personalized metabolic and genetic profile assessments in neurodegenerative disease management.

大分子中性氨基酸、代谢综合征和载脂蛋白E ε4对中年大脑完整性的相互影响
导言 大分子中性氨基酸(LNAA)色氨酸和苯丙氨酸与神经退行性疾病的发病机制有关。鉴于有关 LNAA 在不同生命阶段、血管风险和遗传背景下对大脑健康影响的研究有限,我们的研究旨在探讨 LNAA 水平、代谢综合征(MetS)和中年时载脂蛋白 E ε4(载脂蛋白 E ε4)等位基因大脑完整性的相互作用。方法 68 名 40-61 岁的成年人接受了健康评估,以计算 MetS 成分的数量、量化 LNAA、测量白质高密度(WMH)体积以及载脂蛋白 E ε4 的基因型。在调整性别、年龄和教育程度的同时,进行多变量线性回归分析,以检验LNAA、MetS和载脂蛋白E ε4对WMH的共同影响。结果 在血清色氨酸(β = 0.042,SE = 0.018,p < 0.05)和苯丙氨酸(β = 0.044,SE = 0.013,p < 0.01)水平、MetS成分数量和载脂蛋白E ε4等位基因状态对WMH体积的影响之间观察到了显著的三方交互作用。单个 LNAA 水平或 MetS 成分均不能单独预测 WMH 体积。结论 该研究强调了 LNAA、MetS 和遗传风险因素在 WMH 病理中的显著三向相互作用,尤其是在易患阿尔茨海默病的遗传个体中。这些相互作用表明,LNAA 对 WMH 体积的不同影响取决于遗传和代谢因素。研究结果强调了在神经退行性疾病管理中进行个性化代谢和遗传特征评估的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信