The effects of nonsoy legumes consumption on serum levels of inflammatory biomarkers and Adiponectin in overweight/obese adults: A systematic review and meta-analysis of randomized controlled trials

IF 4.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

Abstract

Nonsoy legumes offer many health benefits, including improved arterial function, reduced cholesterol levels, and better management of cardiovascular diseases and type 2 diabetes. This systematic review and meta-analysis aim to clarify the inconclusive findings from randomized controlled trials (RCTs) by comprehensively evaluating the effects of nonsoy legumes consumption on serum levels of inflammatory biomarkers and Adiponectin. The search encompassed databases up to January 2024, including PubMed, EMBASE, MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL to retrieve all RCTs examining the effects of nonsoy legumes on inflammatory biomarkers or Adiponectin. The effect sizes quantified as mean differences (MD) and standard deviations (SD) of outcomes, and an overall effect estimate was derived using a random-effects model. RCTs examining serum levels of C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-1β (IL-1β), and Adiponectin were included in the final meta-analysis. Results revealed that consumption of nonsoy legumes increased Adiponectin serum levels (P=.0017) and reduced IL-1β serum levels (P<.0001). However, it may not significantly affect CRP (P=.2951), IL-6 (P=.2286), and TNF-α (P=.6661) levels. Subgroup analyses showed that nonsoy legumes consumption significantly decreased TNF-α serum levels in studies involving healthy participants. Additionally, sensitivity analysis using the leave-one-out method suggested a potential significant reduction in serum levels of IL-6. This study indicates that consuming nonsoy legumes can increase levels of Adiponectin and decrease serum levels of IL-1β in overweight or obese adults.

食用非大豆豆类对超重/肥胖成年人血清中炎症生物标志物和脂肪连接蛋白水平的影响:随机对照试验的系统回顾和荟萃分析。
目的:非大豆豆类食品对健康有许多益处,包括改善动脉功能、降低胆固醇水平、更好地控制心血管疾病和 2 型糖尿病。本系统综述和荟萃分析旨在通过全面评估食用非大豆豆类对血清中炎症生物标志物和脂肪连接蛋白水平的影响,澄清随机对照试验(RCT)中的不确定结论:搜索范围涵盖截至 2024 年 1 月的数据库,包括 PubMed、EMBASE、MEDLINE、Scopus、Web of Science 和 Cochrane CENTRAL,以检索所有研究非大豆豆类对炎症生物标志物或脂肪连素影响的 RCT。效应大小以结果的平均差(MD)和标准差(SD)量化,并使用随机效应模型得出总体效应估计值:最终的荟萃分析纳入了研究血清中 C 反应蛋白 (CRP)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、白细胞介素-1β (IL-1β) 和脂肪连素水平的研究。结果显示,食用非大豆豆类可提高脂肪连素的血清水平(p = 0.0017),降低 IL-1β 的血清水平(p < 0.0001)。然而,它可能不会明显影响 CRP(p = 0.2951)、IL-6(p = 0.2286)和 TNF-α (p = 0.6661)的水平。分组分析表明,在涉及健康参与者的研究中,食用非大豆豆类可显著降低TNF-α血清水平。此外,使用撇除法进行的敏感性分析表明,IL-6 的血清水平可能会显著降低:本研究表明,食用非大豆豆类可提高超重或肥胖成年人的脂肪连素水平,并降低其血清中的 IL-1β 水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry 医学-生化与分子生物学
CiteScore
9.50
自引率
3.60%
发文量
237
审稿时长
68 days
期刊介绍: Devoted to advancements in nutritional sciences, The Journal of Nutritional Biochemistry presents experimental nutrition research as it relates to: biochemistry, molecular biology, toxicology, or physiology. Rigorous reviews by an international editorial board of distinguished scientists ensure publication of the most current and key research being conducted in nutrition at the cellular, animal and human level. In addition to its monthly features of critical reviews and research articles, The Journal of Nutritional Biochemistry also periodically publishes emerging issues, experimental methods, and other types of articles.
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