Multiple medications and quality of life of Nigerians with primary open angle glaucoma.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-06 DOI:10.1177/11206721241272179
Chinasa Anderline Nnubia, Sebastian Ndulue Ntuko Nwosu, Nonso Ejikeme Okpala, Akunne Ijeoma Apakama, Ifeanyi James Orji, Chizoba Udoka Uba-Obiano, Adaora Amaoge Onyiaorah
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引用次数: 0

Abstract

Purpose: To determine the impact of multiple medications on the quality of life of primary open angle glaucoma (POAG) patients on medical treatment at Guinness Eye Centre Onitsha, Nigeria.

Materials and methods: Adult patients diagnosed with POAG who were undergoing medical therapy were selected through systematic sampling. They were asked to provide information on socio-demographic background, the number and types of glaucoma medications they were using and any adverse effects encountered while using these medications. The patients' quality of life was assessed by utilizing the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) and all patients completed ocular examination. Data analysis was with Statistical Package for Social Sciences (SPSS) version 23.

Results: One hundred and seventy-one patients, aged 40-83 years, mean 59.1 ± 11.1 were studied; there were 79(46.2%) males and 92(53.8%) females. One hundred and nine (63.7%) patients were on multiple medications. Side effects of treatment increased with increasing number of medications. The mean quality of life score in monotherapy group and double therapy group were 89.3 ± 15.8 and 80.2 ± 21.1 respectively; while that in ≥ triple therapy group was 78.9 ± 18.8. This decrease in mean quality of life score with increasing number of medications was statistically significant in bivariate analysis (P < 0.01), however, multiple regression analysis showed that the number of medications did not significantly affect the quality of life scores after adjusting for confounding variables(p = 0.881).

Conclusion: Among the patients studied, use of multiple medications, unlike visual acuity (VA) and severity of glaucoma, was not an independent predictor of quality of life.

尼日利亚原发性开角型青光眼患者的多种药物治疗和生活质量。
目的:确定多种药物对尼日利亚奥尼沙吉尼斯眼科中心接受药物治疗的原发性开角型青光眼(POAG)患者生活质量的影响:通过系统抽样选取被诊断为正在接受药物治疗的原发性开角型青光眼(POAG)成人患者。要求他们提供有关社会人口背景、正在使用的青光眼药物的数量和类型以及使用这些药物时遇到的任何不良反应的信息。患者的生活质量通过美国国家眼科研究所视觉功能问卷-25(NEI-VFQ-25)进行评估,所有患者均完成了眼部检查。数据分析采用社会科学统计软件包(SPSS)第 23 版:研究对象为 171 名患者,年龄在 40-83 岁之间,平均 59.1 ± 11.1;其中男性 79 人(46.2%),女性 92 人(53.8%)。有 109 名患者(63.7%)服用多种药物。随着药物数量的增加,治疗的副作用也随之增加。单药治疗组和双药治疗组的平均生活质量评分分别为 89.3 ± 15.8 和 80.2 ± 21.1;而≥三药治疗组的平均生活质量评分为 78.9 ± 18.8。在双变量分析中,随着药物数量的增加,平均生活质量评分下降,这一点具有统计学意义(P P = 0.881):结论:在所研究的患者中,与视力(VA)和青光眼严重程度不同,使用多种药物并不是生活质量的独立预测因素。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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