SARS-CoV-2 infection vs. vaccination during pregnancy: the placenta leads the way.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.1097/QCO.0000000000001050

Leire Pérez-Latorre, Octavio Ramilo

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引用次数: 0

Abstract

Purpose of review: To understand the characteristics and determinants of transplacental antibody transfer against SARS-CoV-2 and to compare the differences between SARS-CoV-2 infection and vaccination.

Recent findings: The need for information during the COVID-19 pandemic and the exclusion of pregnant women from randomized clinical trials have led to a vast amount of clinical data primarily based on observational studies with diverse design and sample analyses that yield variable results. This review aims to critically and comprehensively integrate the relevant knowledge related to transplacental transfer of antibodies against SARS-CoV-2, emphasizing the differences between infection and vaccination.

Summary: Passive immunization is key to conferring protection to the infant during their first months of life. Understanding the mechanisms of transplacental antibody transfer during SARS-CoV-2 infection and vaccination, and their associated protection will allow optimizing the implementation of well tolerated and effective preventive strategies for both pregnant women and infants.

查看原文本刊更多论文

孕期感染 SARS-CoV-2 与接种疫苗：胎盘起主导作用。

综述目的了解SARS-CoV-2经胎盘抗体转移的特点和决定因素，比较SARS-CoV-2感染和接种疫苗之间的差异：由于在 COVID-19 大流行期间对信息的需求以及孕妇被排除在随机临床试验之外，导致大量临床数据主要基于观察性研究，而观察性研究的设计和样本分析各不相同，结果也不尽相同。本综述旨在批判性地、全面地整合与 SARS-CoV-2 经胎盘转移抗体相关的知识，强调感染与接种疫苗之间的差异。了解 SARS-CoV-2 感染和接种疫苗期间经胎盘抗体转移的机制及其相关的保护作用，将有助于为孕妇和婴儿优化实施耐受性良好且有效的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.