Respiratory viral infections in children with cancer and febrile neutropenia and children undergoing hematopoietic stem cell transplantation.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.1097/QCO.0000000000001049

Juan P Torres, María E Santolaya

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引用次数: 0

Abstract

Purpose of review: The scope of this review is to understand the epidemiology and potential role of respiratory viral infections in children with cancer and febrile neutropenia, as well as in children, undergoing hematopoietic stem cell transplantation. Early detection of respiratory viral infections through molecular diagnostic techniques has allowed recent randomized clinical studies to advance the possibility of more rational use of antimicrobials in this susceptible population.

Recent findings: Progress has been made in the early detection of respiratory viruses in episodes of fever and neutropenia in children with cancer. In selected patients who meet specific clinical safety criteria and have negative bacterial cultures, it has been possible to safely and effectively discontinue antimicrobials. This has been validated in recent randomized clinical studies. However, more evidence is still needed for a similar indication in children, undergoing hematopoietic stem cell transplantation with viral respiratory infection episodes.

Summary: Understanding the role of respiratory viral infections in populations of immunocompromised children may contribute to a more rational use of antimicrobials and, in the near future, may help to decrease antimicrobial resistance in this susceptible population.

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癌症和发热性中性粒细胞减少症患儿以及接受造血干细胞移植患儿的呼吸道病毒感染。

综述目的：本综述旨在了解呼吸道病毒感染在癌症和发热性中性粒细胞减少症患儿以及造血干细胞移植患儿中的流行病学和潜在作用。通过分子诊断技术对呼吸道病毒感染进行早期检测，使最近的随机临床研究得以推进在这一易感人群中更合理使用抗菌药物的可能性：癌症患儿发热和中性粒细胞减少时呼吸道病毒的早期检测已取得进展。对于符合特定临床安全标准且细菌培养阴性的特定患者，可以安全有效地停用抗菌药物。最近的随机临床研究已经验证了这一点。小结：了解呼吸道病毒感染在免疫力低下儿童群体中的作用，有助于更合理地使用抗菌药物，并在不久的将来帮助减少这一易感人群对抗菌药物的耐药性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.