Angiogenesis in breast cancer: insights and innovations.

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Ghada Elayat, Abdel Selim
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引用次数: 0

Abstract

This review explores the pivotal role of angiogenesis in breast cancer progression and treatment. It covers biomarkers, imaging techniques, therapeutic approaches, resistance mechanisms, and clinical implications. Key topics include Vascular Endothelial Growth Factors, angiopoietins, microRNA signatures, and circulating endothelial cells as biomarkers, along with Magnetic Resonance Imaging, Computed Tomography Angiography, Ultrasound, and Positron Emission Tomography for imaging. Therapeutic strategies targeting VEGF, tyrosine kinase inhibitors, and the intersection of angiogenesis with immunotherapy are discussed. Challenges such as resistance mechanisms and personalized medicine approaches are addressed. Clinical implications, prognostic value, and the future direction of angiogenesis-targeted therapies are highlighted. The article concludes with reflections on the transformative potential of understanding angiogenesis.

乳腺癌的血管生成:见解与创新。
这篇综述探讨了血管生成在乳腺癌进展和治疗中的关键作用。内容涉及生物标志物、成像技术、治疗方法、抗药性机制和临床意义。主要内容包括作为生物标记物的血管内皮生长因子、血管生成素、microRNA 标志和循环内皮细胞,以及用于成像的磁共振成像、计算机断层扫描血管造影、超声波和正电子发射断层扫描。会议还讨论了针对血管内皮生长因子、酪氨酸激酶抑制剂的治疗策略,以及血管生成与免疫疗法的交叉。还讨论了抗药性机制和个性化医疗方法等挑战。文章强调了血管生成靶向疗法的临床意义、预后价值和未来方向。文章最后对了解血管生成的变革潜力进行了反思。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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