Freezing does not influence the microarchitectural parameters of the microstructure of the freshly harvested femoral head bone.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-09-01 Epub Date: 2024-08-05 DOI:10.1007/s10561-024-10147-y
Virginie Taillebot, Théo Krieger, Aurélien Maurel-Pantel, Youngji Kim, Matthieu Ollivier, Martine Pithioux
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引用次数: 0

Abstract

The femoral head is one of the most commonly used bones for allografts and biomechanical studies. However, there are few reports on the trabecular bone microarchitectural parameters of freshly harvested trabecular bones. To our knowledge, this is the first study to characterize the microstructure of femoral heads tested immediately after surgery and compare it with the microstructure obtained with conventional freezing. This study aims to investigate whether freezing at -80 °C for 6 weeks affects the trabecular microstructure of freshly harvested bone tissue. This study was divided into two groups: one with freshly harvested human femoral heads and the other with the same human femoral heads frozen at -80 °C for 6 weeks. Each femoral head was scanned using an X-ray microcomputed tomography scanner (µCT) to obtain the microarchitectural parameters, including the bone volume fraction (BV/TV), the mean trabecular thickness (Tb.th), the trabecular separation (Tb.sp), the degree of anisotropy (DA), and the connectivity density (Conn.D). There was no statistically significant difference between the fresh and the frozen groups for any of the parameters measured. This study shows that freezing at -80 °C for 6 weeks does not alter bone microstructure compared with freshly harvested femoral heads tested immediately after surgery.

Abstract Image

冷冻不会影响新采集股骨头的微观结构参数。
股骨头是异体移植和生物力学研究中最常用的骨骼之一。然而,关于新鲜采集的骨小梁微结构参数的报道却很少。据我们所知,这是第一项对手术后立即测试的股骨头微观结构进行表征并与传统冷冻法获得的微观结构进行比较的研究。本研究旨在探讨-80 °C冷冻6周是否会影响新鲜采集骨组织的骨小梁显微结构。这项研究分为两组:一组是新鲜采集的人类股骨头,另一组是在-80 °C下冷冻6周的相同人类股骨头。使用 X 射线微计算机断层扫描仪(µCT)对每个股骨头进行扫描,以获得微结构参数,包括骨体积分数(BV/TV)、平均骨小梁厚度(Tb.th)、骨小梁分离度(Tb.sp)、各向异性程度(DA)和连接密度(Conn.D)。新鲜组和冷冻组所测量的任何参数在统计学上都没有明显差异。这项研究表明,与手术后立即测试的新鲜股骨头相比,在-80 °C下冷冻6周不会改变骨的微观结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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