Atherogenic Combined Index: Validation of a Novel Predictive Lipid Biomarker for the Presence and Severity of Coronary Artery Disease

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2024-08-03 DOI:10.1016/j.arcmed.2024.103065

Kenan Toprak , Mustafa Kaplangöray , Mesut Karataş , Ayten Dursun , Yakup Arğa , Mustafa Begenc Tascanov , Asuman Biçer , Recep Demirbağ

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引用次数: 0

Abstract

Background/Aim

The balance between atherogenic and antiatherogenic lipid particles significantly influences coronary artery disease (CAD), as an imbalance may contribute to the development and progression of atherosclerosis, which affects the risk and severity of CAD. This study aims to introduce and validate the atherogenic combined index (ACI) as a novel lipid biomarker that, comprehensively assesses the balance between atherogenic and antiatherogenic particles in the blood to effectively reflect the cumulative atherogenic effect and its association with the presence and severity of CAD.

Material and Methods

In this cross-sectional study, 1,830 patients diagnosed with CAD and a total of 650 patients without CAD were included in the study cohort for comprehensive analysis and comparison. Based on the tertiles of the SYNTAX score (SS), three subgroups of patients with CAD were identified. ACI and other atherogenic indices were compared to predict the presence and severity of CAD.

Results

The levels of ACI and other non-traditional lipid markers levels were higher in the CAD group compared to the non-CAD group (p <0.05, for all). ACI showed a good linear association with the SYNTAX score (r = 0.527; p <0.001). The multivariate logistic regression model showed that ACI was an independent predictor of the presence (OR: 1.602, 95% CI: 1.509–1.701, p <0.001) and severity (OR: 1.296, 95% CI: 1.243–1.351, p <0.001) of CAD after adjustment for various confounders.

Conclusion

The results suggest that ACI may serve as a promising and stronger tool for predicting the presence and severity of CAD.

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致动脉粥样硬化综合指数：验证冠状动脉疾病存在和严重程度的新型预测性血脂生物标记物

背景/目的：致动脉粥样硬化脂质颗粒和抗动脉粥样硬化脂质颗粒之间的平衡对冠状动脉疾病（CAD）有重要影响，因为不平衡可能导致动脉粥样硬化的发生和发展，从而影响冠状动脉疾病的风险和严重程度。本研究旨在引入并验证致动脉粥样硬化综合指数（ACI），作为一种新型脂质生物标志物，它能全面评估血液中致动脉粥样硬化颗粒和抗动脉粥样硬化颗粒之间的平衡，从而有效反映累积的致动脉粥样硬化效应及其与冠状动脉粥样硬化的存在和严重程度的关系：在这项横断面研究中，共纳入了 1,830 名确诊为 CAD 的患者和 650 名未确诊为 CAD 的患者进行综合分析和比较。根据 SYNTAX 评分（SS）的三等分，确定了三个 CAD 患者亚组。比较了 ACI 和其他致动脉粥样硬化指数，以预测是否存在 CAD 及其严重程度：结果：与非 CAD 组相比，CAD 组的 ACI 水平和其他非传统血脂标志物水平更高（p 结论：ACI 和其他非传统血脂标志物可预测 CAD 的存在和严重程度：结果表明，ACI 可作为预测是否存在 CAD 及其严重程度的一种有前途且更有力的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.