The global burden, trends and cross-country inequalities of female breast and gynaecologic cancers: A population based study.

IF 4.7 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Bjog-An International Journal of Obstetrics and Gynaecology Pub Date : 2024-08-05 DOI:10.1111/1471-0528.17925

Liangxing Cheng, Zhihong Wang, Rufeng Li, Min Qiang, Chen Yang, Guoer Yang, Yingying Xie, Ruixia Yuan, Yungang Xu

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引用次数: 0

Abstract

Objective: To analyse the global burden, trends and cross-country inequalities of female breast and gynaecologic cancers (FeBGCs).

Design: Population-Based Study.

Setting: Data sourced from the Global Burden of Disease Study 2019.

Population: Individuals diagnosed with FeBGCs.

Methods: Age-standardised mortality rates (ASMRs), age-standardised Disability-Adjusted Life Years (DALYs) rates (ASDRs) and their 95% uncertainty interval (UI) described the burden. Estimated annual percentage changes (EAPCs) and their confidence interval (CI) of age-standardised rates (ASRs) illustrated trends. Social inequalities were quantified using the Slope Index of Inequality (SII) and Concentration Index.

Main outcome measures: The main outcome measures were the burden of FeBGCs and the trends in its inequalities over time.

Results: In 2019, the ASDRs per 100 000 females were as follows: breast cancer: 473.83 (95% UI: 437.30-510.51), cervical cancer: 210.64 (95% UI: 177.67-234.85), ovarian cancer: 124.68 (95% UI: 109.13-138.67) and uterine cancer: 210.64 (95% UI: 177.67-234.85). The trends per year from 1990 to 2019 were expressed as EAPCs of ASDRs and these: for Breast cancer: -0.51 (95% CI: -0.57 to -0.45); Cervical cancer: -0.95 (95% CI: -0.99 to -0.89); Ovarian cancer: -0.08 (95% CI: -0.12 to -0.04); and Uterine cancer: -0.84 (95% CI: -0.93 to -0.75). In the Social Inequalities Analysis (1990-2019) the SII changed from 689.26 to 607.08 for Breast, from -226.66 to -239.92 for cervical, from 222.45 to 228.83 for ovarian and from 74.61 to 103.58 for uterine cancer. The concentration index values ranged from 0.2 to 0.4.

Conclusions: The burden of FeBGCs worldwide showed a downward trend from 1990 to 2019. Countries or regions with higher Socio-demographic Index (SDI) bear a higher DALYs burden of breast, ovarian and uterine cancers, while those with lower SDI bear a heavier burden of cervical cancer. These inequalities increased over time.

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女性乳腺癌和妇科癌症的全球负担、趋势和跨国不平等：一项基于人口的研究。

目的分析全球女性乳腺癌和妇科癌症（FeBGCs）的负担、趋势和跨国不平等现象：设计：基于人群的研究：数据来源：2019 年全球疾病负担研究：方法：年龄标准化死亡率（%）：年龄标准化死亡率（ASMRs）、年龄标准化残疾调整生命年（DALYs）率（ASDRs）及其95%不确定区间（UI）描述了疾病负担。年龄标准化比率（ASRs）的估计年度百分比变化（EAPCs）及其置信区间（CI）说明了趋势。使用不平等斜率指数（SII）和集中指数对社会不平等现象进行量化：主要结果衡量指标为非乙肝患者的负担及其不平等程度随时间变化的趋势：2019年，每10万名女性的ASDR如下：乳腺癌：473.83（95% UI：437.30-510.51）、宫颈癌：210.64（95% UI：177.67-234.85）、卵巢癌：124.68（95% UI：109.13-138.67）和子宫癌：210.64（95% UI：177.67-234.85）。1990 年至 2019 年的每年趋势以 ASDR 的 EAPCs 表示，其中：乳腺癌：-0.51 (95% CI: -0.57 to -0.45)；宫颈癌：-0.95 (95% CI: -0.99 to -0.89)；卵巢癌：-0.08 (95% CI: -0.12 to -0.04)；子宫癌：-0.84 (95% CI: -0.93 to -0.75)。在社会不平等分析（1990-2019 年）中，乳腺癌的 SII 从 689.26 变为 607.08，宫颈癌的 SII 从-226.66 变为-239.92，卵巢癌的 SII 从 222.45 变为 228.83，子宫癌的 SII 从 74.61 变为 103.58。浓度指数值从 0.2 到 0.4 不等：从 1990 年到 2019 年，全球铁布衫癌的负担呈下降趋势。社会人口指数（SDI）较高的国家或地区在乳腺癌、卵巢癌和子宫癌方面的残疾调整寿命年数负担较高，而社会人口指数较低的国家或地区在宫颈癌方面的负担较重。这些不平等现象随着时间的推移而加剧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bjog-An International Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

10.90

自引率

5.20%

发文量

345

审稿时长

3-6 weeks

期刊介绍： BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.