Effect of stevia on blood glucose and HbA1C: A meta-analysis

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM
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引用次数: 0

Abstract

Background

The study investigates substituting non-nutritive sweeteners (NNS) for sugar to address health concerns related to excess sugar intake. It specifically examines how stevia affects insulin and blood glucose levels. The systematic review and meta-analysis aim to evaluate stevia's impact on glycemic indices.

Methods

We conducted a systematic review and meta-analysis following PRISMA guidelines, including 26 studies with 1439 participants. The PROSPERO registration number for this research is CRD42023414411. We systematically searched PubMed (MEDLINE), Scopus, Web of Science, and Google Scholar. Additionally, we thoroughly reviewed the reference lists of the articles we extracted and relevant reviews. Two evaluators independently carried out screening, quality assessment, and data extraction. The GRADE (grading of recommendations, assessment, development, and evaluation) approach was utilized to evaluate the certainty of the evidence.

Results

Stevia consumption was associated with significantly reducing blood glucose levels (WMD: −3.84; 95 % CI: −7.15, −0.53; P = 0.02, low certainty), especially in individuals with higher BMI, diabetes, and hypertension. Dose-response analysis revealed a decrease in blood glucose for ≥3342 mg/day of stevia consumption. Stevia consumption has been shown to reduce blood glucose levels within 1–4 months, as evidenced by dose-response analysis (less than 120 days) and subgroup analysis (more than four weeks). However, stevia did not significantly affect insulin concentration or HbA1C levels (very low and low certainty, respectively).

Conclusions

Low certainty evidence showed that stevia improved blood glucose control, especially when consumed for less than 120 days. However, more randomized trials with higher stevia dosages are required.

甜菊糖对血糖和 HbA1C 的影响:一项荟萃分析。
背景:该研究调查了用非营养性甜味剂(NNS)代替糖来解决与摄入过量糖有关的健康问题。它特别研究了甜菊糖如何影响胰岛素和血糖水平。系统综述和荟萃分析旨在评估甜菊糖对血糖指数的影响:我们按照 PRISMA 指南进行了系统综述和荟萃分析,包括 26 项研究和 1439 名参与者。本研究的 PROSPERO 注册号为 CRD42023414411。我们系统地检索了 PubMed (MEDLINE)、Scopus、Web of Science 和 Google Scholar。此外,我们还仔细查阅了所摘录文章的参考文献目录和相关综述。两名评估人员独立进行筛选、质量评估和数据提取。我们采用 GRADE(建议、评估、发展和评价的分级)方法来评估证据的确定性:食用甜菊糖可显著降低血糖水平(WMD:-3.84;95 % CI:-7.15,-0.53;P = 0.02,低确定性),尤其是在体重指数(BMI)较高、患有糖尿病和高血压的人群中。剂量-反应分析表明,甜菊糖摄入量≥3342 毫克/天,血糖就会下降。剂量反应分析(少于 120 天)和亚组分析(超过四周)显示,食用甜菊糖可在 1-4 个月内降低血糖水平。然而,甜菊糖并未对胰岛素浓度或 HbA1C 水平产生显著影响(确定性分别为极低和较低):低确定性证据显示,甜菊糖可改善血糖控制,尤其是在食用甜菊糖少于 120 天的情况下。然而,还需要更多甜菊糖用量更大的随机试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
22.90
自引率
2.00%
发文量
248
审稿时长
51 days
期刊介绍: Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.
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