Analyzing quality of life after low anterior resection for rectal cancer.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI:10.1007/s11845-024-03757-8

Seyed Mostafa Meshkati Yazd, Reza Shahriarirad, Shayan Almasi, Darioush Naddaffard, Saman Sheikhi, Imana Mosayebi, Kimia Goudarzi, Seyed Mohsen Ahmadi Tafti, Behnam Behboudi, Alireza Kazemeini, Mohammad Reza Keramati

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引用次数: 0

Abstract

Background: Rectal cancer is one of the most common cancers worldwide that imposes high costs on patients and the healthcare system while also having a significant impact on the patient's quality of life (QoL).

Aim: We aimed to assess the QoL of rectal cancer patients undergoing lower anterior resection (LAR) and evaluate potential confounding factors.

Methods: In this cross-sectional study, we included patients undergoing neo-adjuvant chemotherapy followed by LAR, diverting ileostomy, and adjuvant chemotherapy. Six months after stoma reversal, QoL was assessed using a cancer-specific core questionnaire EORTC QLQ-C30 and also a colorectal cancer module EORTC QLQ-CR29. Linear and quantile regression models were used to examine associations of QoL and patients' demographical and clinical features.

Results: The study population comprised 210 patients with an average age of 61.9 ± 11.0 (range: 37-85) and 112 (53.3%) male patients. The higher tumor stage increases the QoL of patients by reducing diarrhea, loss of appetite, defecation problems, and stool frequency. Based on the linear regression analysis, a farther distance of the anastomosis from the anal verge (AV) was correlated with lower symptom scores and higher QoL. Also, at the 75th percentile cut-off of the QLQ-CR29 scores, a higher N stage of the tumor was correlated with higher QoL based on functional subscale (coefficient = 3.032, P = 0.016).

Conclusions: QoL of patients after LAR for rectal cancer is significantly associated with the distance of the anastomosis site from the AV.

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分析直肠癌低位前切除术后的生活质量。

背景：直肠癌是全球最常见的癌症之一：直肠癌是全球最常见的癌症之一，给患者和医疗系统带来了高昂的费用，同时也对患者的生活质量（QoL）产生了重大影响。目的：我们旨在评估接受下段前切除术（LAR）的直肠癌患者的 QoL，并评估潜在的混杂因素：在这项横断面研究中，我们纳入了接受新辅助化疗后进行 LAR、分流回肠造口术和辅助化疗的患者。造口翻转6个月后，我们使用癌症特异性核心问卷EORTC QLQ-C30和结直肠癌模块EORTC QLQ-CR29对患者的生活质量进行了评估。研究采用线性回归和量子回归模型来检验 QoL 与患者的人口统计学特征和临床特征之间的关系：研究对象包括 210 名患者，平均年龄为（61.9±11.0）岁（范围：37-85），其中男性患者 112 名（53.3%）。肿瘤分期越高，患者的生活质量越高，腹泻、食欲不振、排便困难和大便次数减少。根据线性回归分析，吻合口距离肛门边缘（AV）越远，症状评分越低，生活质量越高。此外，在QLQ-CR29评分的第75百分位截断点，肿瘤N分期越高与功能分量表的QoL越高相关（系数=3.032，P=0.016）：结论：直肠癌 LAR 术后患者的 QoL 与吻合部位距离 AV 的远近显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.