Novel therapeutics in development for the treatment of stimulant-use disorder

IF 4.8 2区 医学 Q1 NEUROSCIENCES
Erica J. Young , Laszlo Radnai , Victor Prikhodko , Courtney A. Miller
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引用次数: 0

Abstract

Misuse and accidental overdoses attributed to stimulants are escalating rapidly. These stimulants include methamphetamine, cocaine, amphetamine, ecstasy-type drugs, and prescription stimulants such as methylphenidate. Unlike opioids and alcohol, there are no therapies approved by the US Food and Drug Administration (FDA) to treat stimulant-use disorder. The high rate of relapse among this population highlights the insufficiency of current treatment options, which are limited to abstinence support programs and behavioral modification therapies. Here, we briefly outline recent regulatory actions taken by FDA to help support the development of new stimulant use disorder treatments and highlight several new therapeutics in the clinical development pipeline.

正在开发治疗兴奋剂使用障碍的新型疗法。
兴奋剂的滥用和意外过量正在迅速升级。这些兴奋剂包括甲基苯丙胺、可卡因、苯丙胺、摇头丸类药物以及哌醋甲酯等处方兴奋剂。与阿片类药物和酒精不同,美国食品和药物管理局(FDA)没有批准治疗兴奋剂使用障碍的疗法。这一人群的高复发率凸显了当前治疗方案的不足,这些方案仅限于禁欲支持计划和行为矫正疗法。在此,我们简要概述了美国食品药品管理局最近采取的监管行动,这些行动有助于支持开发新的兴奋剂使用障碍治疗方法,并重点介绍了几种正在临床开发中的新疗法。
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来源期刊
Current Opinion in Neurobiology
Current Opinion in Neurobiology 医学-神经科学
CiteScore
11.10
自引率
1.80%
发文量
130
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience
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