Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Medical Science Pub Date : 2024-08-01 Epub Date: 2024-08-03 DOI:10.1007/s11596-024-2919-6

Jun-Feng Zhang, Feng-Qing Cai, Xiu-Cai Zhang, Qing Ye

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引用次数: 0

Abstract

Objective: Inflammation is involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). The monocyte to high-density lipoprotein cholesterol ratio (MHR) has emerged as a marker for various inflammation-related diseases. The aim of the present study was to investigate the association between the MHR and NAFLD in a population with childhood obesity.

Methods: Based on hepatic ultrasound, a total of 504 children with obesity (357 with NAFLD and 147 without NAFLD) were included in the study. The correlation between the MHR and NAFLD risk factors was assessed by Pearson's and Spearman's analyses. Multivariate stepwise logistic regression analyses were conducted to explore the association between the MHR and the risk of NAFLD.

Results: The MHR in patients with NAFLD was significantly greater than that in patients without NAFLD [0.52 (0.44-0.67) versus 0.44 (0.34-0.57), P<0.001]. Multivariate stepwise logistic regression analysis demonstrated that the MHR [odds ratio (OR): 1.033, 95% confidence interval (CI): 1.015-1.051; P<0.001] was an independent predictor of NAFLD in childhood obesity patients, as were age (OR: 1.205, 95% CI: 1.059-1.371; P=0.005], waist circumference [OR: 1.037, 95% CI: 1.008-1.067; P=0.012], and alanine transaminase [OR: 1.067, 95% CI: 1.045-1.089; P<0.001]. Additionally, MHR quartiles showed a significant positive association with the incidence of NAFLD after adjusting for potential confounding factors.

Conclusion: The present study showed that the MHR may serve as an available and useful indicator of NAFLD in individuals with childhood obesity.

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单核细胞与高密度脂蛋白胆固醇比值作为儿童肥胖症非酒精性脂肪肝的预测指标。

目的：炎症参与了非酒精性脂肪肝（NAFLD）的发生和发展。单核细胞与高密度脂蛋白胆固醇比值（MHR）已成为各种炎症相关疾病的标志物。本研究旨在调查儿童肥胖人群中单核细胞与高密度脂蛋白胆固醇比值与非酒精性脂肪肝之间的关系：方法：根据肝脏超声波，研究共纳入 504 名肥胖儿童（357 名患有非酒精性脂肪肝，147 名未患有非酒精性脂肪肝）。通过皮尔逊和斯皮尔曼分析评估了MHR与非酒精性脂肪肝风险因素之间的相关性。研究人员进行了多变量逐步逻辑回归分析，以探讨MHR与非酒精性脂肪肝风险之间的关系：结果：非酒精性脂肪肝患者的MHR明显高于非酒精性脂肪肝患者[0.52（0.44-0.67）对0.44（0.34-0.57），PC结论：本研究表明，MHR可作为儿童肥胖症患者非酒精性脂肪肝的有效指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.