Adipose stem cell-derived exosomes in the treatment of wound healing in preclinical animal models: a meta-analysis.

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2024-08-04 eCollection Date: 2024-01-01 DOI:10.1093/burnst/tkae025

Jing-Tao Wei, Ting He, Kuo Shen, Zhi-Gang Xu, Jun-Tao Han, Xue-Kang Yang

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引用次数: 0

Abstract

Background: Wound healing has always been a serious issue for doctors and primary health care systems. In addition, adipose stem cell-derived exosomes have been proven to play a positive and effective role in tissue repair and regeneration. A systematic review of these preclinical studies was performed to assess the efficacy of adipose stem cell-derived exosomes (ADSC-Exos) in treating wounds. This article aimed to study the effectiveness of ADSC-Exos for the treatment of animal skin wounds and includes a meta-analysis of exosomes from general wounds and diabetic ulcer wounds in in vitro models of animals to provide a theoretical basis for clinical translation.

Methods: A total of 19 studies with 356 animals were identified by searching the PubMed, Cochrane, MEDLINE Complete, Web of Science, CNKI and Wanfang databases from inception to 15 November 2022. No language or time restrictions were applied. Stata17 was used for all the data analyses.

Results: The meta-analysis showed that ADSC-Exo therapy significantly improved the wound healing rate in the control group, except in the diabetes group on day 7. Day 7 of general wounds [standard mean difference (SMD) 2.87, 95% confidence interval (CI) 1.91-3.83)] and day 14 (SMD 2.89, 95%CI 1.47-4.30). Day 14 (SMD 3.43, 95%CI 1.28-5.58) of diabetic wounds. Other outcomes, such as blood vessel density, collagen deposition and wound re-epithelization, improved with the administration of ADSC-Exos.

Conclusions: A meta-analysis showed that ADSC-Exo therapy applied to general and diabetic wounds can promote neovascularization, improve epithelization and collagen fiber deposition, promote healing, and reduce scar formation. ADSC-Exos have broad potential in preclinical research and clinical fields.

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在临床前动物模型中治疗伤口愈合的脂肪干细胞衍生外泌体：一项荟萃分析。

背景介绍伤口愈合一直是医生和初级卫生保健系统面临的严峻问题。此外，脂肪干细胞衍生的外泌体已被证明可在组织修复和再生中发挥积极有效的作用。我们对这些临床前研究进行了系统回顾，以评估脂肪干细胞衍生外泌体（ADSC-Exos）在治疗伤口方面的功效。本文旨在研究脂肪干细胞外泌体治疗动物皮肤伤口的有效性，并对一般伤口和糖尿病溃疡伤口的动物体外模型外泌体进行了荟萃分析，为临床转化提供理论依据：方法：通过检索 PubMed、Cochrane、MEDLINE Complete、Web of Science、CNKI 和 Wanfang 数据库（从开始到 2022 年 11 月 15 日），共发现 19 项研究，涉及 356 只动物。没有语言或时间限制。所有数据分析均使用Stata17：荟萃分析表明，ADSC-Exo疗法显著提高了对照组的伤口愈合率，但糖尿病组在第7天除外。一般伤口第 7 天[标准平均差（SMD）2.87，95% 置信区间（CI）1.91-3.83]，第 14 天（SMD 2.89，95%CI 1.47-4.30）。糖尿病伤口第 14 天（SMD 3.43，95%CI 1.28-5.58）。其他结果，如血管密度、胶原沉积和伤口重新上皮，也随着 ADSC-Exos 的施用而得到改善：荟萃分析表明，对一般伤口和糖尿病伤口应用 ADSC-Exo 疗法可促进血管新生、改善上皮化和胶原纤维沉积、促进伤口愈合并减少疤痕形成。ADSC-Exos在临床前研究和临床领域具有广泛的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.