Prediabetes and the Risk of Peripheral Artery Disease: A Meta-Analysis

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-02 DOI:10.1016/j.avsg.2024.06.045

Yan Zhang, Bo Song, Yifan Wang, Yu Sun

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引用次数: 0

Abstract

Background

Peripheral artery disease (PAD) is a significant vascular condition that can lead to severe complications, including limb ischemia and cardiovascular events. This meta-analysis aims to evaluate the association between prediabetes, an intermediate state between normoglycemia and diabetes, and the risk of developing PAD.

Methods

A comprehensive search of PubMed, EMBASE, and Web of Science databases was conducted to identify relevant cohort studies up to April 12, 2024. Data extraction was performed independently by 2 reviewers, and any discrepancies were resolved by consensus. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random effects model to account for heterogeneity among studies.

Results

A total of 8 cohort studies comprising 90,133 participants were included in the meta-analysis. The pooled analysis revealed that individuals with prediabetes had a significantly higher risk of PAD compared to those with normoglycemia (RR = 1.27; 95% CI: 1.13–1.42; P < 0.001; I² = 55%). Subgroup analyses indicated that the association was stronger in prediabetes defined by mildly elevated hemoglobin A1c (RR: 1.47) compared to those defined by impaired fasting glucose (RR: 1.21) or impaired glucose tolerance (RR: 1.17, p for subgroup difference <0.001). In addition, a stronger association was observed for studies reporting clinically diagnosed PAD compared to studies that included asymptomatic PAD (RR: 1.32 vs. 0.92; p for subgroup difference = 0.02).

Conclusions

This meta-analysis demonstrates a significant association between prediabetes and an increased risk of PAD in a generally community-derived population.

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糖尿病前期与外周动脉疾病风险：一项荟萃分析。

背景：外周动脉疾病（PAD）是一种严重的血管疾病，可导致严重的并发症，包括肢体缺血和心血管事件。本荟萃分析旨在评估糖尿病前期（介于正常血糖和糖尿病之间的中间状态）与罹患 PAD 风险之间的关联：对 PubMed、EMBASE 和 Web of Science 数据库进行了全面检索，以确定截至 2024 年 4 月 12 日的相关队列研究。数据提取由两名审稿人独立完成，如有任何差异，则以协商一致的方式解决。采用随机效应模型计算汇总相对风险（RRs）和95%置信区间（CIs），以考虑研究间的异质性：荟萃分析共纳入了 8 项队列研究，共有 90133 名参与者。汇总分析显示，与血糖正常者相比，糖尿病前期患者患 PAD 的风险明显更高（RR = 1.27，95% CI：1.13-1.42，p < 0.001；I2 = 55%）。亚组分析表明，与空腹血糖受损（RR：1.21）或糖耐量受损（RR：1.17，亚组差异 p <0.001）的糖尿病前期患者相比，血红蛋白 A1c 轻度升高（RR：1.47）的糖尿病前期患者的相关性更强。此外，与包括无症状 PAD 的研究相比，报告临床诊断 PAD 的研究观察到更强的关联性（RR：1.32 对 0.92，亚组差异 p = 0.02）：这项荟萃分析表明，在一般社区人群中，糖尿病前期与PAD风险增加之间存在显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.