Development of a Multi-Band High-Sensitivity Polarization-Independent Absorber: A Biosensor for Simultaneous Detection of Multiple Cancer Biomarkers

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Yousef Rafighirani, Javad Javidan, Hamid Heidarzadeh
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Abstract

Traditionally, biosensors are indeed designed to detect one specific analyte. However, recent advancements in biosensor technology have enabled the development of multiplexed biosensors capable of detecting multiple analytes simultaneously. This work proposes the detection of cervical cancer (HeLa cells), skin cancer (basal cells), and breast cancer (MDA-MB-231 cells) by analyzing the refractive index of these cells. This analysis is based on comparing the absorption spectra of healthy and cancerous cells. The proposed structure comprises three layers: a copper layer with a conductivity of 5.18 × /m, a silicon dioxide layer with a refractive index of 3.9 containing a cross-shaped hole with a depth of 3.5 µm, and a graphene layer. For the basal cell biosensor, the graphene layer is assigned a chemical potential of 0.7 eV; for the HeLa cell biosensor, it is 0.8 eV, and for the MDA-MB-231 cell biosensor, it is 0.9 eV. The absorption output extracted from CST software yields the highest sensitivity values. For basal cell detection, the highest sensitivity (7100) and a figure of merit (FOM) of 22 are achieved in mode B. For HeLa cell detection, a sensitivity of 5250 and FOM of 28 are attained in mode B. Finally, for MDA-MB-231 detection, a sensitivity of 5357 and FOM of 23 are achieved in mode B. This innovation is particularly beneficial in complex biological samples where the presence of multiple analytes may provide more comprehensive diagnostic information. The proposed multi-band high-sensitivity polarization-independent absorber serves as a notable example of this trend, demonstrating the potential for biosensors to evolve toward simultaneous detection of multianalyte targets, such as different types of cancer cells.

Abstract Image

开发多波段高灵敏度偏振无关吸收器:同时检测多种癌症生物标记物的生物传感器
传统的生物传感器实际上是为检测一种特定的分析物而设计的。然而,生物传感器技术的最新进展使得能够同时检测多种分析物的多路复用生物传感器得以发展。本研究提出通过分析宫颈癌(HeLa 细胞)、皮肤癌(基底细胞)和乳腺癌(MDA-MB-231 细胞)细胞的折射率来检测这些癌症。这种分析基于健康细胞和癌细胞吸收光谱的比较。拟议的结构由三层组成:导电率为 5.18 × /m 的铜层、折射率为 3.9 且含有深度为 3.5 µm 的十字形孔的二氧化硅层以及石墨烯层。对于基底细胞生物传感器,石墨烯层的化学势为 0.7 eV;对于 HeLa 细胞生物传感器,化学势为 0.8 eV;对于 MDA-MB-231 细胞生物传感器,化学势为 0.9 eV。从 CST 软件提取的吸收输出产生了最高的灵敏度值。对于基底细胞检测,模式 B 的灵敏度最高(7100),优点系数(FOM)为 22。在检测 HeLa 细胞时,模式 B 的灵敏度为 5250,优点指数为 28。最后,对于 MDA-MB-231 的检测,模式 B 的灵敏度为 5357,FOM 为 23。这一创新尤其适用于复杂的生物样本,因为多种分析物的存在可以提供更全面的诊断信息。所提出的多波段高灵敏度偏振无关吸收器是这一趋势的一个显著例子,展示了生物传感器向同时检测多种分析目标(如不同类型的癌细胞)发展的潜力。
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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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