Washed Microbiota Transplantation Improves the Sleep Quality in Patients with Inflammatory Bowel Disease

IF 3 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2024-08-02 DOI:10.2147/nss.s460882

Qianqian Li, Yujie Liu, Zulun Zhang, Sheng Zhang, Xiao Ding, Faming Zhang

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Abstract

Purpose: There is scarce evidence to support the effectiveness of faecal microbiota transplantation (FMT) in improving sleep among individuals with inflammatory bowel disease (IBD). Our study aimed to evaluate the effect of washed microbiota transplantation (WMT) (the new method of FMT) on the sleep of patients with IBD in short term.
Patients and Methods: This prospective study was conducted as part of two interventional clinical trials (starting on February 2013 and expected to end on December 2025) and placed significant emphasis on evaluating sleep quality in patients with IBD. To measure subjective sleep, we used the Pittsburgh sleep quality index (PSQI). The primary endpoint was the PSQI score one month after WMT.
Results: This stage study included 52 eligible patients evaluated by PSQI questionnaire who underwent WMT from January 2020 to March 2021 and 47 patients were enrolled for analysis. The age of the patients ranged from 13 to 60 years, with a mean of 33.4 years, and 57.4% (25/47) of the patients were male. The PSQI scores for all 47 patients one month after undergoing WMT were significantly lower (Cohen d = 0.59, p < 0.001) compared to the baseline. Moreover, baseline PSQI score was correlated with the difference value of the PSQI score before and after WMT (post-PSQI minus pre-PSQI) (r = 0.61, p < 0.05).
Conclusion: The study suggests that WMT might be a helpful intervention for improving the sleep quality of patients with IBD, encouraging clinicians to consider its use in clinical practice for addressing poor sleep in IBD patients.
Clinical Trial Registration: ClinicalTrials.gov; ID: NCT01793831, NCT01790061.

Keywords: faecal microbiota transplantation, transendoscopic enteral tubing, sleep disorder, Crohn’s disease, ulcerative colitis, inflammatory bowel disease

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洗净微生物群移植可改善炎症性肠病患者的睡眠质量

目的：很少有证据支持粪便微生物群移植（FMT）在改善炎症性肠病（IBD）患者睡眠方面的有效性。我们的研究旨在评估冲洗微生物群移植（WMT）（FMT 的新方法）对 IBD 患者睡眠的短期影响：这项前瞻性研究是两项干预性临床试验（2013 年 2 月开始，预计 2025 年 12 月结束）的一部分，重点评估 IBD 患者的睡眠质量。为了测量主观睡眠，我们使用了匹兹堡睡眠质量指数（PSQI）。主要终点是WMT一个月后的PSQI评分：这项阶段性研究纳入了 52 名符合 PSQI 问卷评估条件的患者，他们在 2020 年 1 月至 2021 年 3 月期间接受了 WMT，其中 47 名患者被纳入分析。患者年龄从 13 岁到 60 岁不等，平均年龄为 33.4 岁，57.4%（25/47）的患者为男性。与基线相比，所有 47 名患者在接受 WMT 治疗一个月后的 PSQI 分数都明显降低（Cohen d = 0.59，p < 0.001）。此外，基线 PSQI 分数与 WMT 前后 PSQI 分数的差值（PSQI 后减去 PSQI 前）相关（r = 0.61，p < 0.05）：研究表明，WMT可能是一种有助于改善IBD患者睡眠质量的干预措施，鼓励临床医生在临床实践中考虑使用WMT来解决IBD患者睡眠质量差的问题：临床试验注册：ClinicalTrials.gov；ID：NCT01793831、NCT01790061.关键词：粪便微生物群移植、经内镜肠管、睡眠障碍、克罗恩病、溃疡性结肠炎、炎症性肠病

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.

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