{"title":"Improvement of Asymmetric Reactions via Remote Electronic Tuning of N‐Heterocyclic Carbene Catalysts","authors":"Tsubasa Inokuma, Ken-ichi Yamada","doi":"10.1002/cctc.202401078","DOIUrl":null,"url":null,"abstract":"Aminoindanol‐derived N‐heterocyclic carbene catalysts have been widely used to achieve highly enantioselective reactions. Recently, substitution at the indane moiety of the catalysts has been found to have a great impact on the outcome of some reactions, even though the substituted position is distant from the carbene catalytic center. Especially, the introduction of an electron‐withdrawing group improves the yield and enantioselectivity. This review provides an overview of recent reports on the improvement of N‐heterocyclic‐carbene‐catalyzed asymmetric reactions by introducing electron‐withdrawing remote substituents.","PeriodicalId":141,"journal":{"name":"ChemCatChem","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemCatChem","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cctc.202401078","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Aminoindanol‐derived N‐heterocyclic carbene catalysts have been widely used to achieve highly enantioselective reactions. Recently, substitution at the indane moiety of the catalysts has been found to have a great impact on the outcome of some reactions, even though the substituted position is distant from the carbene catalytic center. Especially, the introduction of an electron‐withdrawing group improves the yield and enantioselectivity. This review provides an overview of recent reports on the improvement of N‐heterocyclic‐carbene‐catalyzed asymmetric reactions by introducing electron‐withdrawing remote substituents.
期刊介绍:
With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.