Congenital and acquired hypothyroidism: Temporal and spatial trends in France from 2014 to 2019

IF 3.3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2024-07-31 DOI:10.1016/j.annepidem.2024.07.091

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引用次数: 0

Abstract

Purpose

To assess the incidence of congenital hypothyroidism (CH) and acquired hypothyroidism (AH) between 2014 and 2019 in continental France.

Methods

New cases of CH and AH were identified using the French National Health Data System (Système Nationale des Données de Santé, SNDS). Temporal trends were studied using linear regression models. Spatial distributions were studied using Moran's global index (I) and the statistical method and local indicators of spatial association.

Results

The incidence of permanent CH in females increased by 8.9 % per year (2014: 36.9 [31.1–43.7] per 100,000 birth-years vs. 2019: 51 [43.9–59.3] per 100,000 birth-years, p < 0.01). The incidence of AH decreased between 2014 and 2019 for both females (2014: 535.7 [533.2–538.2] per 100,000 person-years vs 2019: 335.5 [333.6–337.4] per 100,000 person-years, p < 0.01) and males (2014: 197.5 [195.9–199] per 100,000 person-years vs 2019: 141.7 [140.4–142.9] per 100,000 person-years, p < 0.01). The incidence of hypothyroidism was high in the Nord-Pas-De-Calais and Lorraine regions (CH and AH).

Conclusions

The incidence of permanent CH in females has increased over time. AH incidence decreased. It seems necessary to investigate environmental factors in the disparity of incidence distribution.

查看原文本刊更多论文

先天性和后天性甲状腺功能减退症：2014 年至 2019 年法国的时空趋势。

目的：评估2014年至2019年法国大陆先天性甲状腺功能减退症（CH）和获得性甲状腺功能减退症（AH）的发病率：通过法国国家健康数据系统（SNDS）确定先天性甲状腺功能减退症和获得性甲状腺功能减退症的新病例。使用线性回归模型研究了时间趋势。使用莫兰总体指数（I）和统计方法以及空间关联的局部指标对空间分布进行了研究：结果：女性永久性CH的发病率每年增加8.9%（2014年：36.9 [31.1-4.42014年：每10万出生年36.9[31.1-43.7]例，2019年：每10万出生年51[43.9-59.3]例，P<0.01）。在 2014 年至 2019 年期间，女性的 AH 发病率均有所下降（2014 年：535.7 [533.7] 每 10 万出生年，2019 年：51 [43.9-59.3] 每 10 万出生年）：女性（2014 年：每 10 万人年 535.7 [533.2-538.2] 例 vs 2019 年：每 10 万人年 335.5 [333.6-337.4] 例，p < 0.01）和男性（2014 年：每 10 万人年 197.5 [195.9-59.3] 例 vs 2019 年：每 10 万人年 335.5 [333.6-337.4] 例，p < 0.012014年：每10万人年197.5 [195.9-199] 例 vs 2019年：每10万人年141.7 [140.4-142.9] 例，p结论：随着时间的推移，女性永久性 CH 的发病率有所上升。AH发病率有所下降。似乎有必要调查发病率分布差异的环境因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.