Charting cancer's course: revealing the role of diet, exercise, and the microbiome in cancer evolution and immunotherapy response.

IF 2.8 3区医学 Q2 ONCOLOGY

Clinical & Translational Oncology Pub Date : 2025-02-01 Epub Date: 2024-08-02 DOI:10.1007/s12094-024-03595-1

Ana Isabel Martin-Quesada, Maeve A Hennessy, Ana Cardeña Gutiérrez

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Abstract

A variety of pathophysiological mechanisms exist by which physical exercise, nutrition, and the microbiome can impact the development of cancer and the response of tumor cells to systemic anti-cancer therapy. Physical exercise positively impacts the different stages of oncological disease and may improve overall survival and quality of life, reduce treatment-associated toxicity, and improve response to immunotherapy. Nutrition impacts quality of life, and novel nutritional regimens and their role in cancer treatment and outcomes are under active investigation. Finally, the microbiome may act as a predictor of response and resistance to immunotherapy. This comprehensive review delves into the interplay between these elements and their impact on oncological outcomes, emphasizing their role in modulating the immune system and enhancing the response to immunotherapy.The data that support the findings of this study are openly available and referenced in the bibliography section.

Abstract Image

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绘制癌症进程图：揭示饮食、运动和微生物组在癌症演变和免疫疗法反应中的作用。

体育锻炼、营养和微生物组可通过多种病理生理机制影响癌症的发展和肿瘤细胞对全身抗癌疗法的反应。体育锻炼对肿瘤疾病的不同阶段都有积极影响，可提高总体生存率和生活质量，减少治疗相关毒性，改善对免疫疗法的反应。营养会影响生活质量，目前正在积极研究新型营养方案及其在癌症治疗和预后中的作用。最后，微生物组可以预测免疫疗法的反应和耐药性。本综述深入探讨了这些因素之间的相互作用及其对肿瘤治疗效果的影响，强调了它们在调节免疫系统和增强免疫疗法反应方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.