Immune response against bacterial infection in organ transplant recipients

IF 1.6 4区 医学 Q4 IMMUNOLOGY
Amir Elalouf, Amit Yaniv-Rosenfeld, Hanan Maoz
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Abstract

This comprehensive review delves into the intricate dynamics between the immune system and bacterial infections in organ transplant recipients. Its primary objective is to fill existing knowledge gaps while critically assessing the strengths and weaknesses of current research. The paper accentuates the delicate balance that must be struck between preventing graft rejection through immunosuppression and maintaining robust immunity against bacterial threats. In this context, personalized medicine emerges as a transformative concept, offering the potential to revolutionize clinical outcomes by tailoring immunosuppressive regimens and vaccination strategies to the unique profiles of transplant recipients. By emphasizing the pivotal role of continuous monitoring, the review underscores the necessity for vigilant surveillance of transplant recipients to detect bacterial infections and associated immune responses early, thereby reducing the risk of severe infections and ultimately improving patient outcomes. Furthermore, the study highlights the significance of the host microbiome in shaping immune responses, suggesting that interventions targeting the microbiome hold promise for enhancing bacterial immunity in transplant recipients, both in research and clinical practice. In terms of future research directions, the review advocates for large-scale, longitudinal studies encompassing diverse patient cohorts to provide more comprehensive insights into post-transplant immune responses. It also advocates integrating multi-omics approaches, including genomics, transcriptomics, proteomics, and microbiome data, to understand immune responses and their underlying mechanisms. In conclusion, this review significantly enriches our understanding of immune responses in transplant recipients. It paves the way for more effective and personalized approaches to managing infections in this complex setting.

器官移植受者对细菌感染的免疫反应。
这篇综合性综述深入探讨了器官移植受者免疫系统与细菌感染之间错综复杂的动态关系。其主要目的是填补现有的知识空白,同时批判性地评估当前研究的优缺点。论文强调了在通过免疫抑制防止移植排斥反应和保持强大免疫力抵御细菌威胁之间必须达成的微妙平衡。在此背景下,个性化医疗成为一个变革性的概念,通过根据移植受者的独特情况定制免疫抑制方案和疫苗接种策略,有望彻底改变临床结果。通过强调持续监测的关键作用,该综述强调了对移植受者进行警惕性监测的必要性,以便及早发现细菌感染和相关的免疫反应,从而降低严重感染的风险,最终改善患者的预后。此外,该研究还强调了宿主微生物组在形成免疫反应方面的重要作用,表明针对微生物组的干预措施有望在研究和临床实践中增强移植受者的细菌免疫力。就未来的研究方向而言,该综述主张开展大规模的纵向研究,涵盖不同的患者队列,以便更全面地了解移植后的免疫反应。综述还提倡整合多组学方法,包括基因组学、转录组学、蛋白质组学和微生物组数据,以了解免疫反应及其内在机制。总之,这篇综述极大地丰富了我们对移植受者免疫反应的理解。它为在这一复杂环境中采用更有效、更个性化的方法管理感染铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Transplant immunology
Transplant immunology 医学-免疫学
CiteScore
2.10
自引率
13.30%
发文量
198
审稿时长
48 days
期刊介绍: Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.
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