Comparison of Negative Symptom Network Structures Between Patients With Early and Chronic Schizophrenia: A Network and Exploratory Graph Analysis.

IF 5.3 1区 医学 Q1 PSYCHIATRY
Harry Kam Hung Tsui, Ting Yat Wong, Min Yi Sum, Sin Ting Chu, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, Yinam Suen, Eric Yu Hai Chen, Sherry Kit Wa Chan
{"title":"Comparison of Negative Symptom Network Structures Between Patients With Early and Chronic Schizophrenia: A Network and Exploratory Graph Analysis.","authors":"Harry Kam Hung Tsui, Ting Yat Wong, Min Yi Sum, Sin Ting Chu, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, Yinam Suen, Eric Yu Hai Chen, Sherry Kit Wa Chan","doi":"10.1093/schbul/sbae135","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Despite the clinical relevance of negative symptoms in schizophrenia, our understanding of negative symptoms remains limited. Although various courses and stages of schizophrenia have been identified, variations in the negative symptom networks between distinct stages of schizophrenia remain unexplored.</p><p><strong>Study design: </strong>We examined 405 patients with early schizophrenia (ES) and 330 patients with chronic schizophrenia (CS) using the Scale for the Assessment of Negative Symptoms. Network analysis and exploratory graph analysis were used to identify and compare the network structures and community memberships of negative symptoms between the two groups. Further, associations between communities and social functioning were evaluated. The potential influences of other symptom domains and confounding factors were also examined.</p><p><strong>Study results: </strong>Multidimensional differences were found in the networks of negative symptoms between ES and CS. The global connectivity strength was higher in the network of ES than in the network of CS. In ES, central symptoms were mainly related to expressive deficits, whereas in CS they were distributed across negative symptom domains. A three-community structure was suggested across stages but with different memberships and associations with social functioning. Potential confounding factors and symptom domains, including mood, positive, disorganization, and excitement symptoms, did not affect the network structures.</p><p><strong>Conclusion: </strong>Our findings revealed the presence of stage-specific network structures of negative symptoms in schizophrenia, with negative symptom communities having differential significance for social functioning. These findings provide implications for the future development of tailored interventions to alleviate negative symptoms and improve functionality across stages.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/schbul/sbae135","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background and hypothesis: Despite the clinical relevance of negative symptoms in schizophrenia, our understanding of negative symptoms remains limited. Although various courses and stages of schizophrenia have been identified, variations in the negative symptom networks between distinct stages of schizophrenia remain unexplored.

Study design: We examined 405 patients with early schizophrenia (ES) and 330 patients with chronic schizophrenia (CS) using the Scale for the Assessment of Negative Symptoms. Network analysis and exploratory graph analysis were used to identify and compare the network structures and community memberships of negative symptoms between the two groups. Further, associations between communities and social functioning were evaluated. The potential influences of other symptom domains and confounding factors were also examined.

Study results: Multidimensional differences were found in the networks of negative symptoms between ES and CS. The global connectivity strength was higher in the network of ES than in the network of CS. In ES, central symptoms were mainly related to expressive deficits, whereas in CS they were distributed across negative symptom domains. A three-community structure was suggested across stages but with different memberships and associations with social functioning. Potential confounding factors and symptom domains, including mood, positive, disorganization, and excitement symptoms, did not affect the network structures.

Conclusion: Our findings revealed the presence of stage-specific network structures of negative symptoms in schizophrenia, with negative symptom communities having differential significance for social functioning. These findings provide implications for the future development of tailored interventions to alleviate negative symptoms and improve functionality across stages.

早期和慢性精神分裂症患者的消极症状网络结构比较:网络和探索性图表分析
背景与假设:尽管阴性症状在精神分裂症中具有临床意义,但我们对阴性症状的了解仍然有限。尽管精神分裂症的不同病程和阶段已被确定,但不同阶段的精神分裂症患者阴性症状网络的差异仍未得到探讨:研究设计:我们使用阴性症状评估量表对 405 名早期精神分裂症(ES)患者和 330 名慢性精神分裂症(CS)患者进行了研究。通过网络分析和探索性图表分析,确定并比较了两组患者消极症状的网络结构和社群成员情况。此外,还评估了社区与社会功能之间的关联。此外,还研究了其他症状领域和混杂因素的潜在影响:研究结果:ES 和 CS 的负面症状网络存在多维差异。ES网络的整体连接强度高于CS网络。在 ES 中,中心症状主要与表达障碍有关,而在 CS 中,中心症状则分布在各个负性症状领域。在各阶段均存在三社区结构,但其成员组成和与社会功能的关联各不相同。潜在的混杂因素和症状领域(包括情绪、积极、混乱和兴奋症状)并不影响网络结构:我们的研究结果表明,精神分裂症患者的阴性症状网络结构具有阶段特异性,阴性症状群对社会功能具有不同的意义。这些发现为今后开发有针对性的干预措施以缓解阴性症状和改善各阶段的功能提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信