Oxidative stress biomarkers in pregnancy: a systematic review.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2024-08-02 DOI:10.1186/s12958-024-01259-x

Abubakar Ibrahim, Martina Irwan Khoo, Engku Husna Engku Ismail, Nik Hazlina Nik Hussain, Anani Aila Mat Zin, Liza Noordin, Sarimah Abdullah, Zaleha Abdullah Mahdy, Nik Ahmad Zuky Nik Lah

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Abstract

Background: This systematic review explores the level of oxidative stress (OS) markers during pregnancy and their correlation with complications. Unlike previous studies, it refrains from directly investigating the role of OS but instead synthesises data on the levels of these markers and their implications for various pregnancy-related complications such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages.

Method: STUDY DESIGN: Utilizing a systematic review approach, we conducted a comprehensive search across databases, including MEDLINE, CINAHL (EBSCOhost), ScienceDirect, Web of Science, and SCOPUS. Our search encompassed all publication years in English.

Results: After evaluating 54,173 records, 45 studies with a low risk of bias were selected for inclusion. This systematic review has underscored the importance of these markers in both physiological and pathological pregnancy states such as preeclampsia, intrauterine growth restrictions, preterm premature rupture of membranes, preterm labour, gestational diabetes mellitus and miscarriages.

Conclusion: This systematic review provides valuable insights into the role of OS in pregnancy and their connection to complications. These selected studies delved deeply into OS markers during pregnancy and their implications for associated complications. The comprehensive findings highlighted the significance of OS markers in both normal and pathological pregnancy conditions, paving the way for further research in this field.

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妊娠期氧化应激生物标志物：系统综述。

背景：本系统综述探讨了孕期氧化应激（OS）指标的水平及其与并发症的相关性。与以往研究不同的是，本研究没有直接调查氧化应激的作用，而是综合了这些标记物的水平及其对各种妊娠相关并发症（如子痫前期、宫内生长受限、胎膜早破、早产、妊娠糖尿病和流产）的影响：研究设计：利用系统性回顾方法，我们对 MEDLINE、CINAHL (EBSCOhost)、ScienceDirect、Web of Science 和 SCOPUS 等数据库进行了全面检索。我们的检索涵盖了所有出版年份的英文文献：结果：在评估了 54,173 条记录后，我们选择了 45 项偏倚风险较低的研究纳入其中。本系统综述强调了这些标记物在生理和病理妊娠状态中的重要性，如子痫前期、宫内生长受限、胎膜早破、早产、妊娠糖尿病和流产：本系统综述为了解操作系统在妊娠中的作用及其与并发症的关系提供了宝贵的见解。这些选取的研究深入探讨了孕期操作系统的标记及其对相关并发症的影响。全面的研究结果凸显了OS标记物在正常和病理妊娠中的重要性，为这一领域的进一步研究铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.