Macular thickness and visual acuity are characterized by a quadratic nonlinear relation in previously treated neovascular AMD eyes.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-02 DOI:10.1177/11206721241265998
Enrico Borrelli, Giacomo Boscia, Francesco Gelormini, Federico Ricardi, Andrea Ghilardi, Paola Marolo, Guglielmo Parisi, Matteo Fallico, Marco Lupidi, Cesare Mariotti, Francesco Bandello, SriniVas Sadda, Michele Reibaldi
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引用次数: 0

Abstract

Purpose: To assess the associations between visual acuity (VA) and retinal thickness in age-related macular degeneration (AMD) eyes treated with anti-vascular endothelial growth factor (VEGF) therapy.

Methods: Sixty-eight patients with neovascular AMD (68 eyes) undergoing anti-VEGF therapy with two years of follow-up imaging data after the initiation of treatment were retrospectively included. Linear and nonlinear regression analyses with curve fitting estimation were performed to explore the relationship between visual acuity and OCT-based parameters at the 3-month and 24-month follow-up visits. Regression analyses were also performed between visual acuity and the retinal thickness deviation which was calculated as the absolute value of the difference between measured and normative retinal thickness values.

Results: The VA was not associated with either foveal (R2 = 0.011 and p = .401 at 3 months; R2 = 0.032 and p = .142 at 24 months) or parafoveal (R2 = 0.045 and p = .081 at 3 months; R2 = 0.050 and p = .055 at 24 months) retinal thicknesses. Compared with the linear models, a quadratic function yielded a relative increase in the R2 coefficients. Conversely, the VA was linearly associated with foveal retinal thickness deviation (R2 = 0.041 and p = .037 at 24 months) and parafoveal retinal thickness deviation (R2 = 0.062 and p = .040 at 3 months; R2 = 0.088 and p = .014 at 24 months) values.

Conclusions: Although there was no linear relationship between retinal thickness and VA, a weak but statistically significant linear relationship could be observed when a retinal thickness deviation was considered. This suggests that deviation-based parameters may be beneficial for structure-function correlations in the context of anti-VEGF therapy for neovascular AMD.

曾接受过治疗的新生血管性黄斑变性眼的黄斑厚度和视力呈二次非线性关系。
目的:评估接受抗血管内皮生长因子(VEGF)治疗的老年性黄斑变性(AMD)患者视力(VA)与视网膜厚度之间的关系:回顾性纳入了 68 名接受抗血管内皮生长因子治疗的新生血管性黄斑变性患者(68 只眼),这些患者在开始治疗后接受了两年的随访成像数据。通过曲线拟合估计进行线性和非线性回归分析,以探讨3个月和24个月随访时视力与基于OCT的参数之间的关系。视力与视网膜厚度偏差之间也进行了回归分析,视网膜厚度偏差的计算方法是测量值与标准视网膜厚度值之差的绝对值:结果:视力与眼窝(3 个月时,R2 = 0.011,p = .401;24 个月时,R2 = 0.032,p = .142)或眼窝旁(3 个月时,R2 = 0.045,p = .081;24 个月时,R2 = 0.050,p = .055)视网膜厚度无关。与线性模型相比,二次函数的 R2 系数相对增加。相反,VA 与眼窝视网膜厚度偏差(24 个月时 R2 = 0.041,p = .037)和眼窝旁视网膜厚度偏差(3 个月时 R2 = 0.062,p = .040;24 个月时 R2 = 0.088,p = .014)值呈线性相关:结论:虽然视网膜厚度和 VA 之间没有线性关系,但如果考虑视网膜厚度偏差,则可以观察到微弱但具有统计学意义的线性关系。这表明,在抗血管内皮生长因子治疗新生血管性黄斑变性的背景下,基于偏差的参数可能有利于结构-功能相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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