"Long-term safety and efficacy of injection mitomycin C(MMC) versus sponge application in trabeculectomies".

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-02 DOI:10.1177/11206721241266981
Devendra Maheshwari, Madhavi Ramanatha Pillai, Priya Hm, Mohideen Abdul Kader, Ramakrishnan Rengappa, Neelam Pawar
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引用次数: 0

Abstract

Aims: To compare the long-term safety and efficacy of subconjunctival injection mitomycin C(MMC) with conventional sponge applied MMC during trabeculectomy.

Methods and material: Retrospective analysis of 98 eyes of 90 patients who underwent trabeculectomy with Mitomycin C were divided into two groups, group 1- sponge (n = 52) and group 2- Injection(n = 46). Follow-up data were collected on day one, day 15, one month, three months, six months, one year, two years and three years. Data from baseline and follow-up visits were analyzed and compared to study the significant difference in intraocular pressure (IOP), number of antiglaucoma medications (AGM) and best corrected visual acuity (BCVA) . P-value of <0.05 was considered statistically significant.

Results: Mean preop IOP was 34.61 ± 13.3 mmHg in group one and 33.07 ± 9.6 mmHg in group two, which reduced to 11.43 ± 3.2 and 11.59 ± 3.2 mmHg at three years (p < 0.001 in both groups) with no significant difference between the groups. Mean number of preoperative AGM was 2.28 ± 0.8 and 2.42 ± 0.7 in group one and two respectively which reduced to 1.19 ± 1.1(p = 0.405) and 0.88 ± 0.9(p = 0.001) at three years. Complete and overall success rates (complete + qualified) were 59.3% and 78.9% in group one and 60.9% and 80.4% in group two at three years. No statistically significant difference was found in complication rates, post-operative interventions, and final visual outcome in both groups.

Conclusions: Subconjunctival Injection MMC was a safe and effective alternative to sponge application with comparable long term surgical outcomes.

"小梁切除术中注射丝裂霉素 C(MMC)与海绵应用的长期安全性和有效性"。
目的:比较结膜下注射丝裂霉素 C(MMC)与传统海绵注射丝裂霉素 C(MMC)在小梁切除术中的长期安全性和有效性:回顾性分析90名接受小梁切除术并使用丝裂霉素C的患者的98只眼睛,将其分为两组,第一组-海绵组(52人)和第二组-注射组(46人)。分别在第 1 天、第 15 天、1 个月、3 个月、6 个月、1 年、2 年和 3 年收集随访数据。对基线和随访数据进行分析和比较,研究眼压(IOP)、抗青光眼药物(AGM)和最佳矫正视力(BCVA)的显著差异。结果的 P 值:第一组术前平均眼压为(34.61 ± 13.3)毫米汞柱,第二组为(33.07 ± 9.6)毫米汞柱,三年后分别降至(11.43 ± 3.2)毫米汞柱和(11.59 ± 3.2)毫米汞柱(P = 0.405),三年后分别降至(0.88 ± 0.9)毫米汞柱(P = 0.001)。三年后,第一组的完全成功率和总成功率(完全成功+合格)分别为 59.3% 和 78.9%,第二组分别为 60.9% 和 80.4%。两组在并发症发生率、术后干预和最终视觉效果方面均无统计学差异:结论:结膜下注射 MMC 是一种安全有效的方法,可替代海绵注射,且长期手术效果相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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