Global disease burden attributable to kidney dysfunction, 1990–2019: A health inequality and trend analysis based on the global burden of disease study

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-07-31 DOI:10.1016/j.diabres.2024.111801

Yingying Yu , Mingyi Zhang , Yuqin Tang , Chunxia Zhai , Wanqin Hu , Guanghui Yu , Hongyu Sun , Ying Xu , Qiqun Zong , Yuqi Liu , Xingyu Gong , Fang Wang , Yanfeng Zou

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the burden of kidney dysfunction (KD), assess socioeconomic inequalities, and project trends in the future.

Methods

Data on deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) were from Global Burden of Disease Study 2019. The Joinpoint regression model was utilized to analyze the temporal trend by the annual percentage change (APC). The slope index and concentration index were employed to evaluate cross-country disparities. The future trend was predicted using an age-period-cohort analysis.

Results

In the past three decades, the death numbers of KD increased from 1,571,720 to 3,161,552, DALYs from 42,090,331 to 76,486,945, YLDs from 5,003,267 to 11,282,484, and YLLs from 37,087,065 to 65,204,461, respectively. The age-standardized rate (ASR) of deaths, DALYs, and YLLs exhibited a declining trend. The ASR of YLDs increased until 2017, then decreased. The slope index and concentration index for DALYs increased from 248.1 to 351.9 and from 40.70 to 57.8. In the future, the ASR of deaths, DALYs, YLDs, and YLLs will remain stable, while their numbers will continue to rise, except for YLLs.

Conclusions

The disease burden of KD remained serious. Tailored interventions should be developed based on national contexts.

查看原文本刊更多论文

1990-2019 年肾功能障碍导致的全球疾病负担：基于全球疾病负担研究的健康不平等和趋势分析。

目的：本研究旨在评估肾功能障碍（KD）的负担、社会经济不平等现象以及未来趋势：本研究旨在评估肾功能障碍（KD）的负担，评估社会经济不平等现象，并预测未来趋势：死亡、残疾调整生命年（DALYs）、残疾生存年（YLDs）和生命损失年（YLLs）数据来自《2019年全球疾病负担研究》。加入点回归模型通过年百分比变化（APC）来分析时间趋势。斜率指数和集中指数用于评估跨国差异。利用年龄-时期-队列分析预测未来趋势：在过去三十年中，KD的死亡人数从1,571,720人增加到3,161,552人，DALY从42,090,331人增加到76,486,945人，YLD从5,003,267人增加到11,282,484人，YLL从37,087,065人增加到65,204,461人。死亡率、残疾调整寿命年数和年均生命损失率的年龄标准化比率（ASR）呈下降趋势。年死亡率的年龄标准化比率在 2017 年前有所上升，随后有所下降。残疾调整寿命年数的斜率指数和集中指数分别从 248.1 上升到 351.9 和从 40.70 上升到 57.8。未来，死亡、DALYs、YLDs 和 YLLs 的 ASR 将保持稳定，除 YLLs 外，其数量将继续上升：结论：KD 的疾病负担依然严重。应根据各国国情制定有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.