Predictors of continuation for asenapine from real-world data in patients with schizophrenia.

IF 3.6 3区 医学 Q1 PSYCHIATRY
Yoshiteru Takekita, Shuichi Hiraoka, Yasuhiro Iwama, Daisuke Matsui, Nobuatsu Aoki, Haruhiko Ogata, Toshiya Funatsuki, Toshiyuki Shimizu, Yuji Murase, Yutaro Shimamoto, Yosuke Koshikawa, Masaki Kato
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Abstract

Background: The continuation rates of pharmacotherapy in schizophrenia exhibit variability, a phenomenon influenced by the specific antipsychotic agent prescribed and patient-related factors such as age and duration of illness. In this context, our study aims to elucidate the predictors of medication continuation for asenapine sublingual tablets, characterized by unique formulation properties.

Methods: Our investigation leveraged real-world data collected through post-marketing surveillance in Japan, comprising 3236 cases. Utilizing multivariate logistic regression analysis, we identified patient-related factors associated with medication continuation as the primary outcome measure, subsequently employing survival analysis for further evaluation. Additionally, adverse event occurrence was assessed as a secondary outcome measure.

Results: Multivariate logistic regression analysis unveiled significant predictors of asenapine continuation, notably including patient-related factors such as a chlorpromazine equivalent dose exceeding 600 mg/day and an illness duration of 25 years or more. While the overall continuation rate stood at 40.6%, patients exhibiting factors such as a chlorpromazine equivalent dose surpassing 600 mg/day or an illness duration exceeding 25 years demonstrated continuation rates of 46.3% and 47.9%, respectively. Remarkably, patients presenting both factors showcased the highest continuation rate at 52.5%.

Conclusions: Our findings shed light on distinct patient-related predictors of asenapine continuation, deviating from those observed with other antipsychotic medications. This underscores the necessity of recognizing that predictive factors for antipsychotic medication continuation vary across different agents. Moving forward, elucidating these predictive factors for various antipsychotic medications holds paramount importance in schizophrenia treatment, facilitating the delivery of tailored therapeutic interventions for individual patients.

从精神分裂症患者的实际数据中预测继续服用阿塞那平的可能性。
背景:精神分裂症患者继续接受药物治疗的比率存在差异,这一现象受处方的特定抗精神病药物以及年龄和病程等患者相关因素的影响。在这种情况下,我们的研究旨在阐明具有独特配方特性的阿塞那平舌下片继续用药的预测因素:我们的调查利用了通过日本上市后监测收集到的真实世界数据,包括 3236 个病例。通过多变量逻辑回归分析,我们确定了与继续用药相关的患者相关因素,并将其作为主要结果指标,随后采用生存分析进行进一步评估。此外,不良事件发生率也作为次要结果进行评估:多变量逻辑回归分析揭示了阿塞那平持续用药的重要预测因素,主要包括氯丙嗪等效剂量超过600毫克/天和病程在25年或以上等患者相关因素。虽然总体继续服药率为 40.6%,但氯丙嗪等效剂量超过 600 毫克/天或病程超过 25 年的患者继续服药率分别为 46.3% 和 47.9%。值得注意的是,同时具备这两个因素的患者继续服药率最高,达到52.5%:我们的研究结果揭示了与患者相关的预测阿塞那平持续用药的独特因素,与其他抗精神病药物的预测因素有所不同。这突出表明,有必要认识到不同药物的抗精神病药物持续用药预测因素各不相同。展望未来,阐明各种抗精神病药物的这些预测因素在精神分裂症治疗中具有极其重要的意义,有助于为个体患者提供量身定制的治疗干预措施。
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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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