Comparative analysis of oxygenator dysfunction in polymethylpentene oxygenators: A pilot study.

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Perfusion-Uk Pub Date : 2024-08-01 DOI:10.1177/02676591241268402

Shan P Modi, Brandon D'Aloiso, Amber Palmer, Stephanie Smith, Peter Arlia, Michael Anselmi, Pablo Sanchez, Raj Ramanan

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引用次数: 0

Abstract

Introduction: Polymethylpentene (PMP) oxygenators serve as the primary oxygenator type utilized for ECMO. With the number of PMP oxygenators available, it has become increasingly important to determine differences among each oxygenator type that can lead to varying metrics of oxygenator dysfunction.

Methods: This study was a retrospective, single-center analysis of adult patients supported on ECMO between December 2020 to December 2021 with varying PMP oxygenators including the Medtronic Nautilus Smart (Minneapolis, MA), the Eurosets AMG PMP (Medolla, Italy) and Getinge Quadrox-iD and the Getinge Cardiohelp HLS Module Advanced System (Gothenberg, Sweden).

Results: A total of 19 patients were included in our study. 10 patients (52.6%) were supported with a Medtronic Nautilus Smart oxygenator, 5 patients (26.3%) were supported with an Eurosets AMG PMP Oxygenator, and 4 patients (21.1%) were supported with either a Getinge Quadrox-iD oxygenator or Getinge Cardiohelp HLS system. Patients supported with Eurosets AMG PMP oxygenators experienced higher resistance and lower post-oxygenator PaO₂ in comparison to other cohorts (p < .02 and < .002 respectively). There was no difference in measured oxygen transfer between cohorts (p = .667). Two patients, both supported by Eurosets AMG PMP, experienced oxygenator failure (p = .094).

Conclusion: Radial flow oxygenators are prone to higher resistance and lower post-oxygenator PaO₂when compared to transverse flow oxygenators. Future larger multicenter studies are required to fully discern the differences between flow-varying polymethylpentene oxygenators and their appropriate cutoffs for oxygenator dysfunction.

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聚甲基戊烯氧合器功能障碍的比较分析：试点研究。

简介：聚甲基戊烯 (PMP) 氧合器是用于 ECMO 的主要氧合器类型。随着 PMP 氧合器的增多，确定每种氧合器之间的差异变得越来越重要，因为这些差异可能导致氧合器功能障碍的指标不同：这项研究是对 2020 年 12 月至 2021 年 12 月期间使用不同 PMP 氧合器（包括美敦力 Nautilus Smart（马萨诸塞州明尼阿波利斯市）、Eurosets AMG PMP（意大利梅多拉市）、Getinge Quadrox-iD 和 Getinge Cardiohelp HLS 模块高级系统（瑞典哥德堡市））进行 ECMO 支持的成人患者进行的回顾性单中心分析：我们的研究共纳入了19名患者。10名患者（52.6%）使用美敦力 Nautilus Smart 氧合器，5名患者（26.3%）使用 Eurosets AMG PMP 氧合器，4名患者（21.1%）使用 Getinge Quadrox-iD 氧合器或 Getinge Cardiohelp HLS 系统。与其他组别相比，使用 Eurosets AMG PMP 氧合器的患者阻力更高，氧合器后的 PaO2 更低（p 分别为 < .02 和 < .002）。不同组别之间的氧传输测量结果没有差异（p = .667）。两名患者（均由 Eurosets AMG PMP 支持）出现氧合器故障（p = .094）：结论：与横向流氧合器相比，径向流氧合器的阻力更大，氧合器后的 PaO2 更低。未来还需要进行更大规模的多中心研究，以全面了解不同流量的聚甲基戊烯氧合器之间的差异及其氧合器功能障碍的适当临界值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Perfusion-Uk 医学-外周血管病

CiteScore

3.00

自引率

8.30%

发文量

203

审稿时长

6-12 weeks

期刊介绍： Perfusion is an ISI-ranked, peer-reviewed scholarly journal, which provides current information on all aspects of perfusion, oxygenation and biocompatibility and their use in modern cardiac surgery. The journal is at the forefront of international research and development and presents an appropriately multidisciplinary approach to perfusion science.

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