Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2024-08-01 DOI:10.12669/pjms.40.7.9495

Xiuyuan Ni, Shigeng Zhou, Congling Wang, Shengheng Chen, Jingdan Hu, Shengjing Zhang

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引用次数: 0

Abstract

Objective: To explore the clinical value of Vitamin-D combined with budesonide/formoterol (BF) and theophylline sodium glycinate (TSG) sustained-release tablets in the treatment of patients with chronic obstructive pulmonary disease (COPD).

Methods: Medical records of 114 patients with CODP, treated in Wenzhou Geriatric Hospital from October 2020 to February 2023, were retrospectively analyzed. Of them, 59 received treatment with Vitamin-D combined with BF and TSG sustained-release tablets (Group-A), and 55 patients received treatment with BF combined with TSG sustained-release tablets (Group-B). Lung function indicators, blood gas status, inflammatory factors, fractional exhaled nitric oxide (FeNO), and 25-hydroxyvitamin D [25(OH)D] levels before and after the treatment in both groups were collected.

Results: After the treatment, lung function indicators, blood gas status, inflammatory factors, FeNO, and 25 (OH) D levels in both groups were significantly improved compared to pretreatment levels, and were significantly better in the Group-A compared to Group-B (P<0.05).

Conclusions: The combination of Vitamin-D, BF, and TSG sustained-release tablets can effectively regulate the blood gas status of patients with COPD, improve lung function, regulate FeNO and 25 (OH) D, and effectively downregulate the levels of inflammatory factors, thus reducing the degree of inflammatory response.

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维生素 D 联合布地奈德/福莫特罗和甘氨酸茶碱钠缓释片治疗慢性阻塞性肺病患者的临床价值。

目的探讨维生素D联合布地奈德/福莫特罗（BF）和甘氨酸茶碱钠缓释片治疗慢性阻塞性肺疾病（COPD）患者的临床价值：方法：回顾性分析温州市老年病医院自2020年10月至2023年2月收治的114例慢性阻塞性肺疾病患者的病历。其中，59名患者接受了维生素D联合BF和TSG缓释片治疗（A组），55名患者接受了BF联合TSG缓释片治疗（B组）。收集两组患者治疗前后的肺功能指标、血气状况、炎症因子、呼出一氧化氮（FeNO）分数和 25-羟维生素 D [25（OH）D]水平：结果：治疗后，两组患者的肺功能指标、血气状况、炎症因子、FeNO和25（OH）D水平与治疗前相比均有明显改善，且A组明显优于B组：维生素D、BF和TSG缓释片联合应用能有效调节慢性阻塞性肺疾病患者的血气状态，改善肺功能，调节FeNO和25（OH）D，有效降低炎症因子水平，从而减轻炎症反应程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.