Clinical Performance Comparison of a Long Versus a Short Axial Field-of-View PET/CT Using EARL-Compliant Reconstructions.

IF 3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1007/s11307-024-01939-5

Mostafa Roya, Johannes H van Snick, Riemer H J A Slart, Walter Noordzij, Gilles N Stormezand, Antoon T M Willemsen, Ronald Boellaard, Andor W J M Glaudemans, Charalampos Tsoumpas, Joyce van Sluis

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引用次数: 0

Abstract

Purpose: To ensure comparable PET/CT image quality between or within centres, clinical inter-system performance comparisons following European Association of Nuclear Medicine Research Ltd. (EARL) guidelines is required. In this work the performance of the long axial field-of-view Biograph Vision Quadra is compared to its predecessor, the short axial field-of-view Biograph Vision.

Procedures: To this aim, patients with suspected tumour lesions received a single weight-based (3 MBq/kg) 2-deoxy-2-[¹⁸F]fluoro-D-glucose injection and underwent routine clinical ( $\sim$ 15 min) scans on the Vision and 3-min scans on the Quadra in listmode in balanced order. Image quality (IQ), image noise (IN), and tumour demarcation (TD) were assessed visually by four nuclear medicine physicians using a 5-point Likert scale and semiquantitative analysis was performed using standardised uptake values (SUVs). Inter-reader agreement was tested using Wilcoxon's signed rank test and the SUVs were statistically compared using a paired t-test.

Results: Twenty patients (mean age, 60 years ± 8.8 [standard deviation], 16 male) were enrolled. Inter-reader agreement ranged from good to very good for IQ and IN (0.62 ≤ W ≤ 0.81), and fair for TD (0.29 ≤ W ≤ 0.39). Furthermore, a significant difference was found for TD (p = 0.015) between the systems, showing improved TD for the Quadra.

Conclusion: This study demonstrates that the Quadra can be used in routine clinical practice with multiple PET/CT systems or in multicentre studies. This system provides comparable diagnostic image quality and semiquantitative accuracy, improved TD, and has the advantage of shorter scan durations.

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使用符合 EARL 标准的重建技术的长轴视场 PET/CT 与短轴视场 PET/CT 的临床性能比较。

目的：为确保中心之间或中心内部 PET/CT 图像质量的可比性，需要按照欧洲核医学研究协会有限公司（EARL）的指导方针进行临床系统间性能比较。(EARL) 指南进行临床系统间性能比较。在这项工作中，长轴视野 Biograph Vision Quadra 的性能与其前身短轴视野 Biograph Vision 进行了比较：为此，疑似肿瘤病灶患者接受了单次基于重量（3 MBq/kg）的 2-脱氧-2-[18F]氟-D-葡萄糖注射，并在 Vision 上进行了常规临床扫描（15 分钟），在 Quadra 上以列表模式按平衡顺序进行了 3 分钟扫描。图像质量（IQ）、图像噪声（IN）和肿瘤分界（TD）由四名核医学医生使用 5 点李克特量表进行目测评估，并使用标准化摄取值（SUV）进行半定量分析。使用 Wilcoxon 符号秩检验检测读片者之间的一致性，使用配对 t 检验对 SUV 进行统计比较：结果：20 名患者（平均年龄为 60 岁 ± 8.8 [标准差]，16 名男性）接受了检查。IQ和IN的读数一致性从良好到非常好（0.62 ≤ W ≤ 0.81），TD的读数一致性一般（0.29 ≤ W ≤ 0.39）。此外，两种系统的 TD 差异很大（p = 0.015），表明 Quadra 的 TD 有所改善：这项研究表明，Quadra 可用于多个 PET/CT 系统的常规临床实践或多中心研究。该系统可提供相当的诊断图像质量和半定量准确性，改善了TD，并具有扫描时间短的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.