Decreased incidence of peritoneal dialysis-associated peritonitis in young children

IF 1.6 4区 医学 Q2 PEDIATRICS
Peong Gang Park, Yo Han Ahn, Hee Gyung Kang, Il-Soo Ha
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Abstract

Aim

Peritonitis is the most common complication of peritoneal dialysis (PD). This study aimed to investigate changes in the incidence, risk factors, microbiology, and clinical outcomes of PD-associated peritonitis in the past decades.

Methods

This was a retrospective study that included children who initiated chronic PD at our institution between 2000 and 2017. The patients were divided into two groups according to the year of initiation: those who initiated PD between 2000 and 2008 and those who initiated PD between 2009 and 2017. The incidence and characteristics of peritonitis were compared between the groups.

Results

A total of 184 patients with a median age of 10.2 years were included in this study. Of the patients, 92 experienced 210 episodes of peritonitis. The incidence rate of peritonitis decreased from 0.35 to 0.21 episodes/patient year during the study period (P = 0.001). During the 2000–2008 period, the 2-year peritonitis-free survival rate was significantly lower for patients under 2 years of age than for the other age groups (P = 0.004), whereas this was not observed during the 2009–2017 period. The multivariable Cox proportional hazard model showed that the <2 years age group had a significantly higher risk of developing peritonitis in the 2000–2008 period. However, this was not evident in the 2009–2017 period.

Conclusions

The incidence of PD-associated peritonitis decreased, particularly in children under 2 years of age. Thus, younger age may not be a risk factor for PD-associated peritonitis.

Abstract Image

降低幼儿腹膜透析相关腹膜炎的发病率。
目的:腹膜炎是腹膜透析(PD)最常见的并发症。本研究旨在调查过去几十年中腹膜透析相关腹膜炎的发病率、风险因素、微生物学和临床结果的变化:这是一项回顾性研究,纳入了 2000 年至 2017 年期间在我院开始接受慢性腹膜透析治疗的患儿。根据起始年份将患者分为两组:2000 年至 2008 年间起始腹膜透析的患者和 2009 年至 2017 年间起始腹膜透析的患者。比较两组患者腹膜炎的发生率和特征:本研究共纳入184名患者,中位年龄为10.2岁。其中,92 名患者经历了 210 次腹膜炎发作。在研究期间,腹膜炎的发病率从 0.35 次/患者年降至 0.21 次/患者年(P = 0.001)。在 2000-2008 年期间,2 岁以下患者的 2 年无腹膜炎生存率明显低于其他年龄组(P = 0.004),而在 2009-2017 年期间未观察到这种情况。多变量考克斯比例危险模型显示,结论:腹膜透析相关腹膜炎的发病率有所下降,尤其是在两岁以下儿童中。因此,年龄较小可能不是腹膜透析相关性腹膜炎的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
5.90%
发文量
487
审稿时长
3-6 weeks
期刊介绍: The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.
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