Can treatment with chondroitin and glucosamine sulphate prevent changes in the articular disc caused by temporomandibular joint osteoarthritis?

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation Pub Date : 2024-08-02 DOI:10.1111/joor.13814

Giulia Giacomini Malaguez, Felipe Ernesto Artuzi, Alexandre Silva Quevedo, Edela Puricelli, Deise Ponzoni

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引用次数: 0

Abstract

Background

Chondroitin and glucosamine sulphates (CGS) are considered structure-modifying drugs and have been studied in the prevention, delay or reversal of structural morphological changes in joints caused by osteoarthritis.

Objective

The aim of the present study was to investigate the action of CGS on the progression of chemically induced osteoarthritis in the temporomandibular joint (TMJ) of rabbits by evaluating the serum levels of tumour necrosis factor (TNF-α) and collagen in the articular discs.

Materials and Methods

A sample of 36 male rabbits was divided into three groups: control (CG), osteoarthritis (OG) and treatment (TG). The disease was induced by intra-articular injection of sodium monoiodoacetate (10 mg/mL) in the OG and TG groups bilaterally. After 10 days, the TG animals received subcutaneous injection of chondroitin sulphates and glucosamine (7.5 mg/kg) and the OG and CG received saline solution (50 μL). Euthanasia times were subdivided into 40 and 100 days. Collagen quantification was performed by biochemical and histological analysis and for the quantification of serum levels of TNF-α, an enzyme immunoassay was used.

Results

The TG showed an increase in the collagen area of the articular disc when compared to the CG and the OG. The increase collagen concentration in the discs did not show a statistically significant difference between the groups. Post-treatment TNF-α levels were significantly lower in TG compared to OG.

Conclusions

The results indicate that CGS treatment delayed the degeneration of the collagen in the TMJ articular disc and reduced serum TNF-α levels, indicating a preventive effect on OA progression.

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使用软骨素和硫酸氨基葡萄糖治疗能否预防颞下颌关节骨关节炎引起的关节盘变化？

背景：软骨素和氨基葡萄糖硫酸盐（CGS）被认为是结构调节药物，已被研究用于预防、延缓或逆转骨关节炎引起的关节结构形态变化：本研究旨在通过评估血清中肿瘤坏死因子（TNF-α）和关节盘中胶原蛋白的水平，研究 CGS 对化学诱导的兔子颞下颌关节（TMJ）骨关节炎进展的作用：将 36 只雄性家兔分为三组：对照组（CG）、骨关节炎组（OG）和治疗组（TG）。在 OG 组和 TG 组的双侧关节内注射单碘乙酸钠（10 毫克/毫升）诱发疾病。10 天后，TG 组动物皮下注射硫酸软骨素和氨基葡萄糖（7.5 mg/kg），OG 组和 CG 组动物注射生理盐水（50 μL）。安乐死时间分为 40 天和 100 天。通过生化和组织学分析对胶原蛋白进行定量，并使用酶免疫测定法对血清中的 TNF-α 水平进行定量：结果：与 CG 和 OG 相比，TG 的关节盘胶原面积有所增加。椎间盘中胶原蛋白浓度的增加在各组之间没有统计学差异。治疗后，TG 组的 TNF-α 水平明显低于 OG 组：结果表明，CGS 治疗可延缓颞下颌关节椎间盘胶原蛋白的退化，降低血清 TNF-α 水平，对 OA 的进展有预防作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.