The Efficacy of GLP-1 Agonists in Treating Substance Use Disorder in Patients: A Scoping Review.

IF 4.2 3区 医学 Q1 SUBSTANCE ABUSE
Journal of Addiction Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI:10.1097/ADM.0000000000001347
Mary R Shen, Kwadwo Owusu-Boaitey, Laura M Holsen, Joji Suzuki
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引用次数: 0

Abstract

Abstract: Substance use disorder (SUD) continues to be a leading cause of morbidity and mortality with limited treatments. There is interest in expanding the use of GLP-1 agonists in treating SUD. However, evidence for safety and efficacy in humans is limited. This review aims to bridge the existing knowledge gap by establishing a baseline of literature in this area to inform future trials and clinical practice. Our inclusion criteria were English peer-reviewed manuscripts reporting on use of GLP-1, GIP, and/or glucagon receptor agonists in treatment of SUDs, excluding case studies. The literature search was performed in accordance to PRISMA guidelines. Five studies were included in this review examining the use of this medication in tobacco use disorder, alcohol use disorder, and cocaine use disorder. No studies regarding substance withdrawal syndrome were identified. The included studies varied widely in terms of patient selection, dose/formulation of GLP-1 agonists, and follow-up. The results of this scoping review are mixed, with 3 studies demonstrating positive results and 2 studies finding no efficacy of this medication on SUD outcomes. It is premature to prescribe this medication off-label to patients. Further research is needed to determine the efficacy of GLP-1 agonists in treating SUD.

GLP-1 激动剂治疗药物滥用障碍患者的疗效:范围综述》。
摘要:药物使用障碍(SUD)仍然是发病和死亡的主要原因,但治疗方法有限。人们有兴趣扩大 GLP-1 激动剂在治疗 SUD 方面的应用。然而,在人体中的安全性和有效性证据有限。本综述旨在通过建立该领域的文献基线来弥补现有的知识差距,为未来的试验和临床实践提供参考。我们的纳入标准是报道使用 GLP-1、GIP 和/或胰高血糖素受体激动剂治疗 SUD 的英文同行评审稿件,不包括病例研究。文献检索按照 PRISMA 指南进行。本综述共纳入了五项研究,探讨了该药物在烟草使用障碍、酒精使用障碍和可卡因使用障碍中的应用。未发现有关药物戒断综合征的研究。所纳入的研究在患者选择、GLP-1 促效剂的剂量/剂型以及随访方面存在很大差异。本次范围界定审查的结果喜忧参半,其中 3 项研究显示了积极的结果,2 项研究发现这种药物对 SUD 结果没有疗效。在标签外为患者开具这种药物还为时过早。要确定 GLP-1 激动剂治疗 SUD 的疗效,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Addiction Medicine
Journal of Addiction Medicine 医学-药物滥用
CiteScore
6.10
自引率
9.10%
发文量
260
审稿时长
>12 weeks
期刊介绍: The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.
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