Association between the systemic immune-inflammation index and erectile dysfunction: A cross-sectional study

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-08-02 DOI:10.1002/iid3.1363

Di Chen, Fuchang Chen, Quanhai Luo, Wenji Fan, Changsheng Chen, Gang Liu

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Abstract

Background

Erectile dysfunction (ED) is associated with inflammation. The systematic immune-inflammation index (SII), as a new inflammation marker, was applied to predict the risk of diseases. However, no research explores the relationship between SII and ED. Hence, the purpose of this study was to investigate the association between SII and ED.

Methods

Related data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001−2004. Based on self-report, all participants were classified into ED and non-ED group. Weighted multivariate regression analysis the relationship between categorical SII and ED in unadjusted and adjusted models. Restricted cubic spline (RCS) was used to examine the association of continuous SII and ED risk. Furthermore, the association between categorical SII and the risk of ED was evaluated among subgroups of age, body mass index, hypertension, diabetes and cardiovascular disease. Finally, weighted multivariate regression analysis and RCS were performed to assessed the connection between SII and the risk of severe ED.

Results

Initially, data on 21,161 participants were obtained. After implementing the inclusion and exclusion criteria, 3436 participants were included in analyses. Weighted multivariate regression analysis demonstrated that Q4 group SII was associated with an increased risk of ED (OR = 1.03, 95% confidence intervals: 1.00−1.05, p = .03). RCS showed SII was nonlinearly associated with the risk of ED, and the inflection point of SII was at 485.530. In addition, subgroup analyses demonstrated that participants in the SII > 485.530 group had a higher ED risk than SII ≤ 485.530 group among subgroups of age ≥50, hypertension, and non-diabetes. Weighted multivariate regression analysis and RCS found no relationship of SII and the risk of severe ED.

Conclusion

In US adults, SII > 485.530 was correlated with an increased risk of ED. While, no significant association between SII and severe ED risk. Additional studies are required to support our results.

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全身免疫炎症指数与勃起功能障碍之间的关系：横断面研究

背景：勃起功能障碍（ED）与炎症有关：勃起功能障碍（ED）与炎症有关。系统性免疫炎症指数（SII）作为一种新的炎症标志物，被用于预测疾病风险。然而，目前还没有研究探讨 SII 与 ED 之间的关系。因此，本研究旨在调查 SII 与 ED 之间的关系：相关数据来自 2001-2004 年美国国家健康与营养调查（NHANES）。根据自我报告，所有参与者被分为 ED 组和非 ED 组。在未调整和调整模型中，对分类 SII 与 ED 之间的关系进行了加权多变量回归分析。限制立方样条曲线（RCS）用于检验连续 SII 与 ED 风险之间的关系。此外，还评估了年龄、体重指数、高血压、糖尿病和心血管疾病等亚组的分类 SII 与 ED 风险之间的关联。最后，通过加权多元回归分析和 RCS 评估了 SII 与严重 ED 风险之间的联系：初步获得了 21 161 名参与者的数据。结果：最初获得了 21 161 名参与者的数据，在执行纳入和排除标准后，有 3436 名参与者被纳入分析。加权多变量回归分析表明，Q4 组 SII 与 ED 风险增加有关（OR = 1.03，95% 置信区间：1.00-1.05，p = .03）。RCS 显示，SII 与 ED 风险呈非线性关系，SII 的拐点位于 485.530。此外，亚组分析表明，在年龄≥50岁、高血压和非糖尿病亚组中，SII>485.530组的参与者比SII≤485.530组的参与者有更高的ED风险。加权多变量回归分析和RCS发现，SII与严重ED风险没有关系：结论：在美国成年人中，SII > 485.530 与发生 ED 的风险增加有关。结论：在美国成年人中，SII > 485.530 与罹患 ED 的风险增加有关，但 SII 与严重 ED 风险之间无明显关联。我们需要更多的研究来支持我们的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology