Correlation study: Bone density and circulating inflammatory markers in postmenopausal patients

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-08-02 DOI:10.1002/iid3.1365

Xingyu Jin, Ye Wang, Huazheng Wang, Lu Wang, Binglong Huan, Chao Liu

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Abstract

Objective

This study aims to investigate the correlation between changes in bone mineral density (BMD) in postmenopausal women and circulating inflammatory markers.

Methods

This retrospective study focused on postmenopausal women admitted to the orthopedic department of Suzhou Benq Medical Center from June 2022 to December 2023, following predetermined inclusion and exclusion criteria. We retrospectively collected data on initial blood routine test results and bone density measurements for all study subjects upon admission, including parameters such as white blood cell count (WBC), C-reactive protein, interleukin-6 (IL-6), and procalcitonin (PCT). Additionally, the systemic immune-inflammation index (SII) was calculated using neutrophil count, lymphocyte count, and platelet count. Statistical analyses using SPSS and GraphPad software were performed to assess the correlation between bone density and inflammatory markers.

Results

Patients were classified into three groups based on BMD results, including 60 individuals in the osteoporosis (OP) group, 127 individuals in the osteopenia group, and 37 individuals in the Normal group, respectively. Principal component analysis analysis suggested that WBC, SII, and postmenopausal OP (PMOP) held significant feature values. Correlation analysis indicated a correlation between WBC (p = 0.021), IL-6 (p = 0.044), SII (p = 0.034), and PMOP. One-way ANOVA analysis revealed significant differences in IL-6 (p = 0.0179), SII (p = 0.0210), and PCT (p = 0.0200) among the three groups. Finally, ROC curve analysis demonstrated that SII (area under the curve = 0.716) has predictive value for PMOP.

Conclusion

This study identified a certain predictive value for PMOP through the assessment of inflammatory markers in peripheral blood using routine blood tests.

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相关研究：绝经后患者的骨密度和循环炎症标志物。

研究目的本研究旨在探讨绝经后妇女骨矿物质密度（BMD）变化与循环炎症标志物之间的相关性：这项回顾性研究的对象是 2022 年 6 月至 2023 年 12 月期间在苏州本克医疗中心骨科住院的绝经后妇女，按照预先确定的纳入和排除标准进行研究。我们回顾性地收集了所有研究对象入院时的初始血常规检测结果和骨密度测量数据，包括白细胞计数（WBC）、C反应蛋白、白细胞介素-6（IL-6）和降钙素原（PCT）等参数。此外，还利用中性粒细胞计数、淋巴细胞计数和血小板计数计算了全身免疫炎症指数（SII）。使用 SPSS 和 GraphPad 软件进行统计分析，以评估骨密度与炎症指标之间的相关性：根据骨密度结果将患者分为三组，其中骨质疏松症（OP）组 60 人，骨质疏松症组 127 人，正常组 37 人。主成分分析表明，WBC、SII 和绝经后 OP（PMOP）具有显著的特征值。相关性分析表明，WBC（p = 0.021）、IL-6（p = 0.044）、SII（p = 0.034）和 PMOP 之间存在相关性。单因素方差分析显示，IL-6（p = 0.0179）、SII（p = 0.0210）和 PCT（p = 0.0200）在三组之间存在显著差异。最后，ROC 曲线分析表明，SII（曲线下面积 = 0.716）对 PMOP 具有预测价值：本研究通过使用血常规检查评估外周血中的炎症标志物，确定了 PMOP 的一定预测价值。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology