Prevalence and factors associated with opioid use disorder among adolescents with sickle cell disease in Mulago hospital, Uganda.

IF 3.4 3区医学 Q1 PEDIATRICS

Child and Adolescent Psychiatry and Mental Health Pub Date : 2024-08-01 DOI:10.1186/s13034-024-00790-4

Claire Kwagala, Deogratias Munube, Catherine Abbo, Wilson Winstons Muhwezi, Emmanuel Kiiza Mwesiga

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引用次数: 0

Abstract

Background: Opioid use disorder (OUD) among adolescents with sickle cell disease (SCD) patients increases their risk of complications from sickle cell disease, such as infections, stroke, acute chest syndrome, sudden death, and organ failure. This negatively impacts families, communities, the national health system, and the economy. This study aimed to determine the prevalence and factors associated with opioid use disorder among adolescents with SCD at Mulago Hospital Uganda.

Methods: This study was carried out at the Sickle Cell Clinic of Mulago Hospital, the national referral hospital in Uganda. The study participants were adolescents aged 10 to 19 years. Following informed consent/ assent, a sociodemographic questionnaire, the WHO Alcohol, Smoking and Substance Involvement Screening Test - Young (ASSIST-Y), the Beck Depression Inventory-II (BDI II), and Generalized Anxiety Disorder - 7 (GAD-7) questionnaires were used to collect data. Data was entered in EpiInfo and analyzed in STATA 15.

Results: The prevalence of opioid use disorder was 5.3%. The significant risk factor was increasing depressive score AOR: 1.11(95% CI: 1.01-1.22, p = 0.035), while living with a family was protective against opioid use disorders AOR: 0.01; (95% CI: 0.0004, 0.27, p = 0.007).

Conclusion: There was a significant problem of OUD among adolescents with SCD. There is, therefore, needed to integrate screening of OUD and mental illnesses like depression among adolescents with SCD and to emphasize the importance of family support in their care.

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乌干达穆拉戈医院患有镰状细胞病的青少年中阿片类药物使用障碍的患病率和相关因素。

背景：患有镰状细胞病 (SCD) 的青少年患者出现阿片类药物使用障碍 (OUD) 会增加他们患上镰状细胞病并发症的风险，如感染、中风、急性胸部综合征、猝死和器官衰竭。这对家庭、社区、国家卫生系统和经济造成了负面影响。本研究旨在确定乌干达穆拉戈医院患有镰状细胞病的青少年中阿片类药物使用障碍的患病率和相关因素：本研究在乌干达国家转诊医院穆拉戈医院镰状细胞诊所进行。研究参与者为 10 至 19 岁的青少年。在获得知情同意/同意后，研究人员使用社会人口学问卷、世卫组织酒精、吸烟和药物卷入筛查测试-青年（ASSIST-Y）、贝克抑郁清单-II（BDI II）和广泛性焦虑症-7（GAD-7）问卷收集数据。数据输入 EpiInfo，并在 STATA 15 中进行分析：结果：阿片类药物使用障碍的患病率为 5.3%。重要的风险因素是抑郁评分的增加，AOR：1.11（95% CI：1.01-1.22，p = 0.035），而与家人同住对阿片类药物使用障碍具有保护作用，AOR：0.01；（95% CI：0.0004，0.27，p = 0.007）：结论：患有 SCD 的青少年中存在严重的 OUD 问题。因此，有必要对患有 SCD 的青少年进行 OUD 和抑郁症等精神疾病的综合筛查，并强调家庭支持在其护理中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Child and Adolescent Psychiatry and Mental Health PEDIATRICSPSYCHIATRY-PSYCHIATRY

CiteScore

7.00

自引率

3.60%

发文量

审稿时长

16 weeks

期刊介绍： Child and Adolescent Psychiatry and Mental Health, the official journal of the International Association for Child and Adolescent Psychiatry and Allied Professions, is an open access, online journal that provides an international platform for rapid and comprehensive scientific communication on child and adolescent mental health across different cultural backgrounds. CAPMH serves as a scientifically rigorous and broadly open forum for both interdisciplinary and cross-cultural exchange of research information, involving psychiatrists, paediatricians, psychologists, neuroscientists, and allied disciplines. The journal focusses on improving the knowledge base for the diagnosis, prognosis and treatment of mental health conditions in children and adolescents, and aims to integrate basic science, clinical research and the practical implementation of research findings. In addition, aspects which are still underrepresented in the traditional journals such as neurobiology and neuropsychology of psychiatric disorders in childhood and adolescence are considered.