One-pot multicomponent approach towards the synthesis of 5-substituted 1H-tetrazoles using lanthanum (III) nitrate hexahydrate as a catalyst

IF 2.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2024-07-31 DOI:10.1007/s11164-024-05365-8

Kumaraswamy Gullapelli, Ramesh Nukala, Saidulu Ganji, Ramesh Kola, Ravichandar Maroju

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Abstract

An intriguing trend in the synthesis of heterocyclic compounds is green chemistry, which involves using environmentally friendly reagents and efficient reactions to suit the demands of the pharmaceutical sector. This study is a part of continuous endeavour to advance novel synthetic approaches for the synthesis of heterocyclic molecules. With lanthanum nitrate hexahydrate as a catalyst, a procedure for the synthesis of tetrazoles was described in this work. The ideal 10% mole ratio of La(NO₃)₃·6H₂O catalyst with DMF solvent produced good yields of the intended products, ranging from 85 to 98%, according to the results. High product yields, cost effectiveness, and operational simplicity are just a few benefits of using La(NO₃)₃·6H₂O as a catalyst in this condensation reaction. The chemical structures of the synthesized tetrazoles were analyzed and characterized using ¹HNMR, ¹³C-NMR, and mass spectra (HRMS).

Graphical abstract

Abstract Image

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以六水合硝酸镧（III）为催化剂合成 5-取代的 1H- 四唑的单锅多组分方法

合成杂环化合物的一个有趣趋势是绿色化学，它涉及使用环保试剂和高效反应，以满足制药行业的需求。这项研究是不断努力推进新合成方法以合成杂环分子的一部分。本研究以六水硝酸镧为催化剂，描述了四唑的合成过程。结果表明，在理想的 10%摩尔比的 La(NO3)3-6H2O 催化剂和 DMF 溶剂的作用下，预期产品的产率很高，从 85% 到 98% 不等。在该缩合反应中使用 La(NO3)3-6H2O 作为催化剂具有产品收率高、成本效益高和操作简单等优点。利用 1HNMR、13C-NMR 和质谱（HRMS）对合成的四唑的化学结构进行了分析和表征。

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.