Effect of the interlayer distribution of ZnO decorated with Ag nanoparticles on the antimicrobial activity of multilayer poly(methyl methacrylate) films

IF 3.8 4区工程技术 Q2 CHEMISTRY, APPLIED

Journal of Vinyl & Additive Technology Pub Date : 2024-07-29 DOI:10.1002/vnl.22146

Miguel Ángel Waldo-Mendoza, Nancy Araceli Rivera-García, Marissa Robles-Martínez, Perla Cristina Mayorga-Colunga, Roberto Carlos Martínez-Montejano, Elías Pérez

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引用次数: 0

Abstract

Incorporating nanoparticles into polymer matrices for enhanced antimicrobial properties is particularly interesting. This study examines how the interlayer distribution of zinc oxide (ZnO) decorated with silver nanoparticles (AgNPs) within poly(methyl methacrylate) (PMMA) films impacts their antimicrobial activity. Various PMMA multilayer films were prepared, with the antimicrobial additive intentionally placed in the outer, core, bottom, or throughout all layers. Their efficacy was tested against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria. Results indicate that E. coli was the strain with the highest sensitivity to the system because it is a gram (−) bacterium, which could generate a lower resistance to AgNPs. On the other hand, S. aureus, being gram (+), presents a thicker lipid membrane, and peptidoglycan wall, which makes it difficult for AgNPs to enter. Films with uniform distribution throughout thickness exhibited the most sustained antimicrobial activity due to high antimicrobial concentration. This study demonstrated that the distribution of the AgNPs/ZnO system in different layers of a PMMA film influences its antimicrobial capacity. Finally, a mechanism for migrating silver ions released from the AgNPs/ZnO system in PMMA films is proposed, highlighting their interactions with bacterial cells and the subsequent antimicrobial effects.

Highlights

Interlayer distribution influences antimicrobial activity.
Outer placement leads to rapid silver ion release.
Core distribution controls antimicrobial kinetics.
Uniform distribution ensures sustained activity.

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用银纳米粒子装饰的氧化锌层间分布对多层聚甲基丙烯酸甲酯薄膜抗菌活性的影响

将纳米粒子融入聚合物基质以增强抗菌性能尤其令人感兴趣。本研究探讨了聚甲基丙烯酸甲酯（PMMA）薄膜中银纳米粒子（AgNPs）装饰的氧化锌（ZnO）的层间分布如何影响其抗菌活性。我们制备了各种 PMMA 多层薄膜，并有意将抗菌添加剂置于外层、核心层、底层或所有层中。测试了这些薄膜对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌的功效。结果表明，大肠杆菌是对该系统最敏感的菌株，因为它是一种革兰氏（-）细菌，可能对 AgNPs 产生较低的抗药性。另一方面，金黄色葡萄球菌是革兰氏（+）菌，具有较厚的脂质膜和肽聚糖壁，使 AgNPs 难以进入。由于抗菌浓度高，厚度分布均匀的薄膜具有最持久的抗菌活性。这项研究表明，AgNPs/ZnO 系统在 PMMA 薄膜不同层中的分布会影响其抗菌能力。最后，提出了从 PMMA 薄膜中的 AgNPs/ZnO 系统释放的银离子的迁移机制，强调了它们与细菌细胞的相互作用以及随后的抗菌效果。外层分布导致银离子快速释放。核心分布控制抗菌动力学。均匀分布可确保持续活性。

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来源期刊

Journal of Vinyl & Additive Technology 工程技术-材料科学：纺织

CiteScore

5.40

自引率

14.80%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Vinyl and Additive Technology is a peer-reviewed technical publication for new work in the fields of polymer modifiers and additives, vinyl polymers and selected review papers. Over half of all papers in JVAT are based on technology of additives and modifiers for all classes of polymers: thermoset polymers and both condensation and addition thermoplastics. Papers on vinyl technology include PVC additives.