Effects of Different Physical Training Protocols on Metabolic Syndrome Indicators and the Activity of Butyrylcholinesterase in Adolescents: A Randomized Clinical Trial

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-07-31 DOI:10.3390/metabo14080422

Giuliano Roberto da Silva, Gerusa Dias Siqueira Vilela Terra, David Michel de Oliveira, Eduardo Vignoto Fernandes, Emerson José Zechin, Arthur Rizzi Soares, Dalton Muller Pessoa-Filho, Cassiano Merussi Neiva

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Abstract

Metabolic syndrome (MS) increases the risk of cardiovascular disease and affects children and adolescents. Butyrylcholinesterase (BChE) is an enzyme associated with obesity. The aim of this study was to investigate the effects of different physical training protocols on MS indicators and their relationship with BChE activity. This randomized clinical trial included 80 adolescents randomly assigned to 4 groups (CG: Control Group; ATG: Aerobic Training Group; STG: Strength Training Group; and CTG: Concurrent Training Group). The EFC, lipid profile, glycemia, waist circumference, and blood pressure were analyzed. With the exception of the CG, all the groups underwent training protocols for 12 consecutive weeks, 4 times a week, as follows: (ATG: 75% of heart rate on an electric treadmill; STG: 85% of 1 maximum repetition; CTG: 20 min of aerobic training at the same intensity as the ATG, and 20 min of resistance training in the same way as the STG). The training reduced MS-related biomarkers, such as the lipid profile, glycemia, waist circumference, and blood pressure. STG reduced BChE activity. The training methods led to improvements in the majority of the MS indicators. In addition, aerobic training significantly reduced BChE activity after a 12-week training protocol. The results suggest that different types of exercise can benefit MS.

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不同体育训练方案对青少年代谢综合征指标和丁酰胆碱酯酶活性的影响：随机临床试验

代谢综合征（MS）会增加罹患心血管疾病的风险，并影响儿童和青少年。丁酰胆碱酯酶（BChE）是一种与肥胖有关的酶。本研究旨在探讨不同体育训练方案对 MS 指标的影响及其与 BChE 活性的关系。这项随机临床试验包括 80 名青少年，他们被随机分配到 4 个组（CG：对照组；ATG：有氧训练组；STG：力量训练组；CTG：同步训练组）。对 EFC、血脂、血糖、腰围和血压进行了分析。除 CG 组外，其他各组都接受了连续 12 周、每周 4 次的训练，具体如下：(ATG：在电动跑步机上以 75% 的心率进行训练；STG：以 85% 的最大重复次数进行训练；CTG：以与 ATG 相同的强度进行 20 分钟的有氧训练，以与 STG 相同的方式进行 20 分钟的阻力训练）。训练降低了与多发性硬化症相关的生物标志物，如血脂、血糖、腰围和血压。STG 降低了 BChE 活性。这些训练方法改善了大多数 MS 指标。此外，在为期12周的训练方案后，有氧训练明显降低了BChE活性。研究结果表明，不同类型的运动对多发性硬化症都有益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.