Design and Optimization of a MXene-Based Terahertz Surface Plasmon Resonance Sensor for Malaria Detection

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2024-07-29 DOI:10.1007/s11468-024-02455-6

Haitham Alsaif, Jacob Wekalao, Naim Ben Ali, Omar Kahouli, Jaganathan Logeshwaran, Shobhit K. Patel, Ammar Armghan

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Abstract

Developing sensitive and specific methods for detecting malaria is a substantial challenge in biomedical research. Here, we introduce a novel approach utilizing a metasurface sensor based on graphene for the detection of malaria. Modelled on a silicon dioxide (SiO₂) substrate, this sensor allows seamless integration with current electronic and optical technologies. The sensor design incorporates square and quadrant-based resonators, optimized through comprehensive parametric analysis to assess their geometric effects on sensor performance. The results demonstrate an enhanced sensitivity of 600 GHzRIU⁻¹. Analysis of the electric field illustrates frequency-dependent transmittance properties, alongside promising 2-bit encoding capabilities. Furthermore, the research establishes a direct correlation between resonance frequency, refractive index, and analyte concentration. This sensor offers a promising avenue for swift, precise, and non-invasive malaria detection, potentially enhancing point-of-care diagnostic capabilities in healthcare settings.

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设计和优化用于疟疾检测的基于 MXene 的太赫兹表面等离子体共振传感器

开发灵敏而特异的疟疾检测方法是生物医学研究的一大挑战。在此，我们介绍一种利用基于石墨烯的元表面传感器检测疟疾的新方法。这种传感器以二氧化硅（SiO2）基底为模型，可与当前的电子和光学技术无缝集成。传感器设计采用了方形和象限谐振器，并通过综合参数分析进行了优化，以评估它们对传感器性能的几何影响。结果表明，灵敏度提高了 600 GHzRIU-1。对电场的分析表明了随频率变化的透射特性，以及有望实现的 2 位编码能力。此外，研究还确定了共振频率、折射率和分析物浓度之间的直接相关性。这种传感器为快速、精确和无创的疟疾检测提供了一个前景广阔的途径，有可能提高医疗机构的床旁诊断能力。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.